| Literature DB >> 16758314 |
Ricardo Schmit T De Bem1, Shirley Ramos Da Ro Sa Utiyama, Renato Mitsunori Nisihara, Jerônimo Antônio Fortunato, Josué Augusto Tondo, Eliane Ribeiro Carmes, Raquel Almada E Souza, Julio César Pisani, Heda Maria Barska Dos Santos Amarante.
Abstract
Celiac disease (CD) is a permanent condition of gluten intolerance and a number of autoimmune diseases have been associated with it. In the past few years, a relation between CD and dilated cardiomyopathy (CM) was described in Europe and United States. The aim of this study was to evaluate the prevalence of CD among south Brazilian precardiac transplant patients with advanced CM. A total of 74 patients on a list for heart transplantation were evaluated for the presence CD. The presence of anti-endomisial antibody (IgA-EmA) was determined by indirect immunofluorescence and for the anti-transglutaminase antibody (IgA anti-h-tTG) by ELISA. Serologically positive patients were submitted to upper endoscopy with intestinal biopsy. Two individuals (2.63%) were positive for IgA-EmA and 5 (6.75%) for IgA anti-h-tTG; 1 (1.35%) had both tests positive. Histologic confirmation of CD occurred only in the IgA-EmA positive patients. In conclusion, data from the present study allows recommend the screening for CD in patients with CM using IgA-EmA test as the method of choice.Entities:
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Year: 2006 PMID： 16758314 DOI： 10.1007/s10620-006-9337-4
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199