S Cottone1, A Palermo, F Vaccaro, F Raspanti, B Buscemi, F Incalcaterra, G Cerasola. 1. Università di Palermo, Italy, Cattedra di Medicina Interna, Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Divisione di Medicina Interna, Nefrologia ed Ipertensione, Palermo, Italy. sancott@tin.it
Abstract
INTRODUCTION: The inflammatory state plays a well-documented role to cause oxidative stress, especially in end-stage renal disease (ESRD) patients, wherein several cardiovascular risk factors are amplified by the coexistence of a microinflammatory state with increased oxidative stress. METHODS: We measured serum concentrations of high sensitivity C-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha), 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha-in vivo oxidative stress marker) in 15 chronic renal failure (CRF) and 15 transplant patients versus 15 healthy controls. Exclusion criteria were: age <30 or >65 years as well as a diagnosis of diabetes or cardiovascular diseases. We evaluated systolic (SBP) and diastolic blood pressure (DBP), serum creatinine (sCr), and glomerular filtration rate (GFR). RESULTS: Both the transplanted and the CRF group showed significantly higher values of CRP, TNFalpha, and 8-iso-PGF2alpha than the controls (P < .05 for all). SBP, DBP, and sCr were not different between transplanted and CRF patients. CRP was higher in transplant recipients than in CRF patients (P < .05). No difference in TNFalpha levels was observed between the two groups. 8-iso-PGF2alpha was significantly higher in the CRF than in the transplanted group (P < .05), although the latter cohort showed a positive correlation between 8-iso-PGF2alpha and TNFalpha (P < .001), sCr (P < .001), SBP (P < .05), and DBP (P < .05). In the same group both 8-iso-PGF2alpha and TNFalpha were negatively correlated with GFR (r -.824 and -.866, respectively; P < .001 for both). CONCLUSION: We observed the coexistence of increased oxidative stress and an inflammatory state among renal graft recipients.
INTRODUCTION: The inflammatory state plays a well-documented role to cause oxidative stress, especially in end-stage renal disease (ESRD) patients, wherein several cardiovascular risk factors are amplified by the coexistence of a microinflammatory state with increased oxidative stress. METHODS: We measured serum concentrations of high sensitivity C-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha), 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha-in vivo oxidative stress marker) in 15 chronic renal failure (CRF) and 15 transplant patients versus 15 healthy controls. Exclusion criteria were: age <30 or >65 years as well as a diagnosis of diabetes or cardiovascular diseases. We evaluated systolic (SBP) and diastolic blood pressure (DBP), serum creatinine (sCr), and glomerular filtration rate (GFR). RESULTS: Both the transplanted and the CRF group showed significantly higher values of CRP, TNFalpha, and 8-iso-PGF2alpha than the controls (P < .05 for all). SBP, DBP, and sCr were not different between transplanted and CRF patients. CRP was higher in transplant recipients than in CRF patients (P < .05). No difference in TNFalpha levels was observed between the two groups. 8-iso-PGF2alpha was significantly higher in the CRF than in the transplanted group (P < .05), although the latter cohort showed a positive correlation between 8-iso-PGF2alpha and TNFalpha (P < .001), sCr (P < .001), SBP (P < .05), and DBP (P < .05). In the same group both 8-iso-PGF2alpha and TNFalpha were negatively correlated with GFR (r -.824 and -.866, respectively; P < .001 for both). CONCLUSION: We observed the coexistence of increased oxidative stress and an inflammatory state among renal graft recipients.
Authors: Camilo G Sotomayor; Nicolas I Bustos; Manuela Yepes-Calderon; Diego Arauna; Martin H de Borst; Stefan P Berger; Ramón Rodrigo; Robin P F Dullaart; Gerjan J Navis; Stephan J L Bakker Journal: Antioxidants (Basel) Date: 2021-04-21
Authors: Cristina Antinozzi; Elisa Grazioli; Maria De Santis; Francesca Motta; Paolo Sgrò; Federico Mari; Caterina Mauri; Attilio Parisi; Daniela Caporossi; Guglielmo Duranti; Roberta Ceci; Luigi Di Luigi; Ivan Dimauro Journal: Int J Environ Res Public Health Date: 2022-08-18 Impact factor: 4.614