BACKGROUND: Recently accumulated evidence has demonstrated that bright-light therapy in combination with antidepressants is effective in patients with non-seasonal major depression. Whether bright light has a sustained effect after discontinuation is, however, poorly investigated. METHOD: In this double-blind randomized study we report the results from a 4-week follow-up period in patients with major non-seasonal depression who had been treated for 5 weeks withsertraline combined with bright-light therapy or sertraline combined with dim-light therapy. At the beginning of the follow-up period the light therapy was stopped while sertraline treatment continued for 4 weeks. RESULTS:Depression scores decreased substantially in both groups, resulting in high response and remission rates in both groups after 9 weeks of treatment. The difference in depression scores at week 5, favouring the bright-light-treated group, disappeared gradually in the 4-week follow-up period, resulting in similar end-point scores. CONCLUSIONS: Bright light did not have a sustained effect after discontinuation. The offset of effect was complete after 4 weeks.
RCT Entities:
BACKGROUND: Recently accumulated evidence has demonstrated that bright-light therapy in combination with antidepressants is effective in patients with non-seasonal major depression. Whether bright light has a sustained effect after discontinuation is, however, poorly investigated. METHOD: In this double-blind randomized study we report the results from a 4-week follow-up period in patients with major non-seasonal depression who had been treated for 5 weeks with sertraline combined with bright-light therapy or sertraline combined with dim-light therapy. At the beginning of the follow-up period the light therapy was stopped while sertraline treatment continued for 4 weeks. RESULTS:Depression scores decreased substantially in both groups, resulting in high response and remission rates in both groups after 9 weeks of treatment. The difference in depression scores at week 5, favouring the bright-light-treated group, disappeared gradually in the 4-week follow-up period, resulting in similar end-point scores. CONCLUSIONS: Bright light did not have a sustained effect after discontinuation. The offset of effect was complete after 4 weeks.
Authors: Davide Elia Bertani; Antonella Maria Pia De Novellis; Riccardo Farina; Emanuela Latella; Matteo Meloni; Carmela Scala; Laura Valeo; Gian Maria Galeazzi; Silvia Ferrari Journal: Int J Environ Res Public Health Date: 2021-02-09 Impact factor: 3.390
Authors: Eve Cosker; Marie Moulard; Samuel Schmitt; Karine Angioi-Duprez; Cédric Baumann; Vincent Laprévote; Raymund Schwan; Thomas Schwitzer Journal: BMJ Open Date: 2021-07-09 Impact factor: 2.692
Authors: Carlo Volf; Anne Sofie Aggestrup; Signe Dunker Svendsen; Torben Skov Hansen; Paul Michael Petersen; Carsten Dam-Hansen; Ulla Knorr; Ema Erkocevic Petersen; Janus Engstrøm; Ida Hageman; Janus Christian Jakobsen; Klaus Martiny Journal: Pilot Feasibility Stud Date: 2020-01-15