Literature DB >> 16755833

T2 fluctuations in ischemic and post-ischemic viable porcine myocardium in vivo.

W D Foltz1, Y Yang, J J Graham, J S Detsky, A J Dick, G A Wright.   

Abstract

T2 relaxation can augment delayed-enhancement viability imaging because it is sensitive to tissue edema and microcirculatory oxygen state. We demonstrate the T2 'signatures' of sub-lethal ischemia and stunning in porcine myocardium perfused by the distal left anterior descending artery, by imaging during percutaneous balloon occlusion for 25 minutes and subsequent reperfusion (n = 9). Muscle displayed ischemic dysfunction and partial post-ischemic functional recovery (p < or = 0.0004), concommitant with an elevated post-ischemic T2 (deltaT2 = 27 +/- 18%, p = 0.005). TTC staining verified muscle viability. The T2 fluctuations may reflect hyperemia and tissue cellular edema in accord with the known pathophysiology of ischemic and post-ischemic yet viable muscle.

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Year:  2006        PMID： 16755833     DOI： 10.1080/10976640600572897

Source DB:  PubMed          Journal:  J Cardiovasc Magn Reson        ISSN： 1097-6647            Impact factor:   5.364


  6 in total

1.  Salvage assessment with cardiac MRI following acute myocardial infarction underestimates potential for recovery of systolic strain.

Authors:  Declan P O'Regan; Ben Ariff; A John Baksi; Fabiana Gordon; Giuliana Durighel; Stuart A Cook
Journal:  Eur Radiol       Date:  2012-11-24       Impact factor: 5.315

2.  Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome.

Authors:  Subha V Raman; Orlando P Simonetti; Marshall W Winner; Jennifer A Dickerson; Xin He; Ernest L Mazzaferri; Giuseppe Ambrosio
Journal:  J Am Coll Cardiol       Date:  2010-06-01       Impact factor: 24.094

3.  Improved quantitative myocardial T2 mapping: Impact of the fitting model.

Authors:  Mehmet Akçakaya; Tamer A Basha; Sebastian Weingärtner; Sébastien Roujol; Sophie Berg; Reza Nezafat
Journal:  Magn Reson Med       Date:  2014-08-07       Impact factor: 4.668

4.  Myocardial tissue characterization by combining late gadolinium enhancement imaging and percent edema mapping: a novel T2 map-based MRI method in canine myocardial infarction.

Authors:  Pal Suranyi; Gabriel A Elgavish; U Joseph Schoepf; Balazs Ruzsics; Pal Kiss; Marly van Assen; Brian E Jacobs; Brigitta C Brott; Ada Elgavish; Akos Varga-Szemes
Journal:  Eur Radiol Exp       Date:  2018-03-16

Review 5.  Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel.

Authors:  Borja Ibanez; Anthony H Aletras; Andrew E Arai; Hakan Arheden; Jeroen Bax; Colin Berry; Chiara Bucciarelli-Ducci; Pierre Croisille; Erica Dall'Armellina; Rohan Dharmakumar; Ingo Eitel; Rodrigo Fernández-Jiménez; Matthias G Friedrich; David García-Dorado; Derek J Hausenloy; Raymond J Kim; Sebastian Kozerke; Christopher M Kramer; Michael Salerno; Javier Sánchez-González; Javier Sanz; Valentin Fuster
Journal:  J Am Coll Cardiol       Date:  2019-07-16       Impact factor: 24.094

6.  Multi-parametric MRI as an indirect evaluation tool of the mechanical properties of in-vitro cardiac tissues.

Authors:  Delphine Périé; Nagib Dahdah; Anthony Foudis; Daniel Curnier
Journal:  BMC Cardiovasc Disord       Date:  2013-03-27       Impact factor: 2.298
  6 in total

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