Literature DB >> 16753574

Ringing the dinner bell for insulin: muscarinic M3 receptor activity in the control of pancreatic beta cell function.

Jesper Gromada1, Thomas E Hughes.   

Abstract

In this issue of Cell Metabolism, Gautam et al. (2006) show that pancreatic beta cell M3 muscarinic acetylcholine receptors control insulin secretion. Their results highlight the role of the M3 receptor subtype in integrating nervous stimuli with metabolic control of insulin secretion and glucose homeostasis.

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Year:  2006        PMID： 16753574     DOI： 10.1016/j.cmet.2006.05.004

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  7 in total

1.  M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.

Authors:  Kok Choi Kong; Adrian J Butcher; Phillip McWilliams; David Jones; Jürgen Wess; Fadi F Hamdan; Tim Werry; Elizabeth M Rosethorne; Steven J Charlton; Sarah E Munson; Hannah A Cragg; Alison D Smart; Andrew B Tobin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

Review 2.  Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor.

Authors:  Katrina Weston-Green; Xu-Feng Huang; Chao Deng
Journal:  CNS Drugs       Date:  2013-12       Impact factor: 5.749

Review 3.  Muscarinic receptor agonists and antagonists: effects on cancer.

Authors:  Eliot R Spindel
Journal:  Handb Exp Pharmacol       Date:  2012

4.  Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors.

Authors:  Jason P Chan; Derek Sieburth
Journal:  J Neurosci       Date:  2012-12-05       Impact factor: 6.167

5.  Molecular mechanisms of muscarinic acetylcholine receptor-stimulated increase in cytosolic free Ca(2+) concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line.

Authors:  Joanne L Selway; Claire E Moore; Rajendra Mistry; R A John Challiss; Terence P Herbert
Journal:  Acta Diabetol       Date:  2011-08-11       Impact factor: 4.280

Review 6.  Employing novel animal models in the design of clinically efficacious GPCR ligands.

Authors:  Sophie J Bradley; Sajjad A Riaz; Andrew B Tobin
Journal:  Curr Opin Cell Biol       Date:  2013-12-31       Impact factor: 8.382

7.  Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

Authors:  Kae Nagasumi; Ritsuko Esaki; Kimihiko Iwachidow; Yoshitaka Yasuhara; Kazuhiro Ogi; Hideyuki Tanaka; Mitsugu Nakata; Takashi Yano; Kozo Shimakawa; Shigehisa Taketomi; Koji Takeuchi; Hiroyuki Odaka; Yoshihiko Kaisho
Journal:  Diabetes       Date:  2009-05       Impact factor: 9.461
  7 in total

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