| Literature DB >> 16752360 |
M Axel Wollmer1, Elisabeth Kapaki, Martin Hersberger, Jörg Muntwyler, Fabienne Brunner, Magdalini Tsolaki, Hiroyasu Akatsu, Kenji Kosaka, Makoto Michikawa, Dimitra Molyva, Giorgos P Paraskevas, Dieter Lütjohann, Arnold von Eckardstein, Christoph Hock, Roger M Nitsch, Andreas Papassotiropoulos.
Abstract
A recent study demonstrated a significant genetic association between the ATP-binding cassette transporter A2 (ABCA2) and the risk for Alzheimer's disease (AD) in a large Caucasian sample. The rare T allele of the synonymous exonic single nucleotide polymorphism (SNP) rs908832 was overrepresented in early-onset AD patients as compared to cognitively healthy controls. Here we confirm the association of rs908832 with AD in a Western European population (n = 291, P = 0.008). In a second sample from Southern Europe, rs908832 was not associated with AD. Interestingly, rs908832 was not polymorphic in a Japanese sample. Furthermore, rs908832 was not associated with either serum cholesterol levels or with the risk for coronary artery disease, but seemed to be related to cholesterol levels in the cerebrospinal fluid. These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease. (c) 2006 Wiley-Liss, Inc.Entities:
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Year: 2006 PMID： 16752360 DOI： 10.1002/ajmg.b.30345
Source DB: PubMed Journal: Am J Med Genet B Neuropsychiatr Genet ISSN： 1552-4841 Impact factor: 3.568