| Literature DB >> 16751092 |
Katherine A Fitzgerald1, Zhijian J Chen.
Abstract
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.Entities:
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Year: 2006 PMID： 16751092 DOI： 10.1016/j.cell.2006.05.014
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582