Literature DB >> 16750231

Miltefosine: issues to be addressed in the future.

J Berman1, A D M Bryceson, S Croft, J Engel, W Gutteridge, J Karbwang, H Sindermann, J Soto, S Sundar, J A Urbina.   

Abstract

Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions.

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Year:  2006        PMID: 16750231     DOI: 10.1016/j.trstmh.2006.02.009

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN: 0035-9203            Impact factor:   2.184


  12 in total

1.  Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Authors:  Georgina A Holloway; William N Charman; Alan H Fairlamb; Reto Brun; Marcel Kaiser; Edmund Kostewicz; Patrizia M Novello; John P Parisot; John Richardson; Ian P Street; Keith G Watson; Jonathan B Baell
Journal:  Antimicrob Agents Chemother       Date:  2009-04-13       Impact factor: 5.191

2.  New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas.

Authors:  Kathryn M Dupnik; Eliana L Nascimento; Joao F Rodrigues-Neto; Tatjana Keesen; Maria Zélia Fernandes; Iraci Duarte; Selma M B Jeronimo
Journal:  Drug Dev Res       Date:  2011-09       Impact factor: 4.360

3.  Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis.

Authors:  Nathan P Wiederhold; Laura K Najvar; Rosie Bocanegra; William R Kirkpatrick; Tania C Sorrell; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2012-11-19       Impact factor: 5.191

4.  Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children.

Authors:  Luisa Consuelo Rubiano; María Consuelo Miranda; Sandra Muvdi Arenas; Luz Mery Montero; Isabel Rodríguez-Barraquer; Daniel Garcerant; Martín Prager; Lyda Osorio; Maria Ximena Rojas; Mauricio Pérez; Ruben Santiago Nicholls; Nancy Gore Saravia
Journal:  J Infect Dis       Date:  2012-01-11       Impact factor: 5.226

5.  The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major.

Authors:  David A Scott; Suzanne M Hickerson; Tim J Vickers; Stephen M Beverley
Journal:  J Biol Chem       Date:  2007-11-02       Impact factor: 5.157

6.  An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1.

Authors:  Neeloo Singh; Jaspreet Kaur; Pranav Kumar; Swati Gupta; Nasib Singh; Angana Ghosal; Avijit Dutta; Ashutosh Kumar; Ramapati Tripathi; Mohammad Imran Siddiqi; Chitra Mandal; Anuradha Dube
Journal:  Parasitol Res       Date:  2009-07-21       Impact factor: 2.289

Review 7.  The relationship between leishmaniasis and AIDS: the second 10 years.

Authors:  Jorge Alvar; Pilar Aparicio; Abraham Aseffa; Margriet Den Boer; Carmen Cañavate; Jean-Pierre Dedet; Luigi Gradoni; Rachel Ter Horst; Rogelio López-Vélez; Javier Moreno
Journal:  Clin Microbiol Rev       Date:  2008-04       Impact factor: 26.132

8.  Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.

Authors:  Thomas P C Dorlo; Pieter P A M van Thiel; Alwin D R Huitema; Ron J Keizer; Henry J C de Vries; Jos H Beijnen; Peter J de Vries
Journal:  Antimicrob Agents Chemother       Date:  2008-06-02       Impact factor: 5.191

9.  Update in the treatment of cutaneous leishmaniasis.

Authors:  Sahar H Al-Natour
Journal:  J Family Community Med       Date:  2009-05

10.  Laboratory confirmed miltefosine resistant cases of visceral leishmaniasis from India.

Authors:  Saumya Srivastava; Jyotsna Mishra; Anil Kumar Gupta; Amit Singh; Prem Shankar; Sarman Singh
Journal:  Parasit Vectors       Date:  2017-01-31       Impact factor: 3.876

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