Literature DB >> 16749813

Regioselective reduction of 3-methoxymaleimides: an efficient method for the synthesis of methyl 5-hydroxytetramates.

Fatiah Issa1, Joshua Fischer, Peter Turner, Mark J Coster.   

Abstract

3-Methoxymaleimide and various N-alkyl-3-methoxymaleimides, synthesized by base-promoted N-alkylation of 3-methoxymaleimide, were reduced using sodium borohydride with complete regioselectivity. The resultant methyl 5-hydroxytetramates are useful intermediates in the synthesis of a variety of tetramate derivatives.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16749813     DOI： 10.1021/jo0605750

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors.

Authors:  Nicholas Pagano; Eric Y Wong; Tom Breiding; Haidong Liu; Alexander Wilbuer; Howard Bregman; Qi Shen; Scott L Diamond; Eric Meggers
Journal:  J Org Chem       Date:  2009-12-04       Impact factor: 4.354

2.  A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids.

Authors:  Johanna Trenner; Evgeny V Prusov
Journal:  Beilstein J Org Chem       Date:  2015-03-06       Impact factor: 2.883
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.