Literature DB >> 16742828

Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).

S Whitehouse1, P J Randle.   

Abstract

The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin+/-acetate+/-dichloroacetate. Dichloroacetate (100mum, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.

Entities:  

Year:  1973        PMID： 16742828      PMCID： PMC1177854          DOI： 10.1042/bj1340651

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies.

Authors:  O Wieland; H v. Funcke; G Löffler
Journal:  FEBS Lett       Date:  1971-07-01       Impact factor: 4.124

2.  Hypoglycaemic action of diisopropyl-ammonium salts in experimental diabetes.

Authors:  M LORINI; M CIMAN
Journal:  Biochem Pharmacol       Date:  1962-09       Impact factor: 5.858

3.  Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.

Authors:  R M Denton; P J Randle; B R Martin
Journal:  Biochem J       Date:  1972-06       Impact factor: 3.857

4.  -Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.

Authors:  T C Linn; J W Pelley; F H Pettit; F Hucho; D D Randall; L J Reed
Journal:  Arch Biochem Biophys       Date:  1972-02       Impact factor: 4.013

5.  Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.

Authors:  T C Linn; F H Pettit; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1969-01       Impact factor: 11.205

6.  Diisopropylammonium dichloroaccetate: regulation of metabolic intermediates in muscle of alloxan diabetic rats.

Authors:  P W Stacpoole; J M Felts
Journal:  Metabolism       Date:  1971-09       Impact factor: 8.694

7.  Diisopropylammonium dichloroacetate (DIPA) and sodium dichloracetate (DCA): effect on glucose and fat metabolism in normal and diabetic tissue.

Authors:  P W Stacpoole; J M Felts
Journal:  Metabolism       Date:  1970-01       Impact factor: 8.694

8.  Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones.

Authors:  H G Coore; R M Denton; B R Martin; P J Randle
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857

9.  The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart.

Authors:  J R Neely; R M Denton; P J England; P J Randle
Journal:  Biochem J       Date:  1972-06       Impact factor: 3.857
  9 in total
  52 in total

1.  A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity.

Authors:  Cheng-Yang Wu; Santhosh Satapati; Wenjun Gui; R Max Wynn; Gaurav Sharma; Mingliang Lou; Xiangbing Qi; Shawn C Burgess; Craig Malloy; Chalermchai Khemtong; A Dean Sherry; David T Chuang; Matthew E Merritt
Journal:  J Biol Chem       Date:  2018-05-08       Impact factor: 5.157

2.  Regulation of mammalian pyruvate dehydrogenase.

Authors:  R M Denton; P J Randle; B J Bridges; R H Cooper; A L Kerbey; H T Pask; D L Severson; D Stansbie; S Whitehouse
Journal:  Mol Cell Biochem       Date:  1975-10-31       Impact factor: 3.396

3.  Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.

Authors:  Anyuan He; Xiaowen Chen; Min Tan; Yali Chen; Dongliang Lu; Xiangyu Zhang; John M Dean; Babak Razani; Irfan J Lodhi
Journal:  Mol Cell       Date:  2020-05-29       Impact factor: 17.970

Review 4.  Lactic acidosis in sepsis: a commentary.

Authors:  G Gutierrez; M E Wulf
Journal:  Intensive Care Med       Date:  1996-01       Impact factor: 17.440

5.  Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes.

Authors:  Y Fischer; U Böttcher; M Eblenkamp; J Thomas; E Jüngling; P Rösen; H Kammermeier
Journal:  Biochem J       Date:  1997-02-01       Impact factor: 3.857

6.  The metabolic effects of sodium dichloroacetate in the suckling newborn rat.

Authors:  J P Pegorier; P Ferré; A Leturque; J Girard
Journal:  Diabetologia       Date:  1978-12       Impact factor: 10.122

7.  Effects of dichloroacetate in the treatment of hypoxic lactic acidosis in dogs.

Authors:  H Graf; W Leach; A I Arieff
Journal:  J Clin Invest       Date:  1985-09       Impact factor: 14.808

8.  Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise.

Authors:  S A Hagg; S I Taylor; N B Ruberman
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857

9.  The effects of pyruvate concentration, dichloroacetate and alpha-cyano-4-hydroxycinnamate on gluconeogenesis, ketogenesis and [3-hydroxybutyrate]/[3-oxobutyrate] ratios in isolated rat hepatocytes.

Authors:  F Demaugre; J P Leroux; P Cartier
Journal:  Biochem J       Date:  1978-04-15       Impact factor: 3.857

10.  Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.

Authors:  B M Madhok; S Yeluri; S L Perry; T A Hughes; D G Jayne
Journal:  Br J Cancer       Date:  2010-05-18       Impact factor: 7.640
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