Literature DB >> 16742444

Enzymic hydrolysis of sphingolipids: Hydrolysis of ceramide lactoside by an enzyme from rat brain.

S Gatt1, M M Rapport.   

Abstract

Ceramide lactoside [1-O-(galactosido-4-beta-glucosido)-2-N-acyl-sphingosine] was hydrolysed to ceramide glucoside and galactose by beta-galactosidase of rat brain. The reaction was not reversible, required cholate or taurocholate, had optimum pH5.0 and K(m) 2.2x10(-5)m. It was inhibited by gamma-galactonolactone and galactose as well as by ceramide, sphingosine and fatty acid. Ceramide lactoside could be degraded to ceramide, galactose and glucose by mixtures of rat-brain beta-galactosidase and ox-brain beta-glucosidase.

Entities:  

Year:  1966        PMID： 16742444      PMCID： PMC1270172     

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  THIN-LAYER CHROMATOGRAPHIC SEPARATION OF SPHINGOSINE AND RELATED BASES.

Authors:  K SAMBASIVARAO; R H MCCLUER
Journal:  J Lipid Res       Date:  1963-01       Impact factor: 5.922

Review 2.  THE GANGLIOSIDES.

Authors:  L SVENNERHOLM
Journal:  J Lipid Res       Date:  1964-04       Impact factor: 5.922

3.  THE SEPARATION OF NEUTRAL BLOOD-SERUM GLYCOLIPIDS BY THIN-LAYER CHROMATOGRAPHY.

Authors:  E SVENNERHOLM; L SVENNERHOLM
Journal:  Biochim Biophys Acta       Date:  1963-08-27

4.  [BRAIN GANGLIOSIDES IN INFANTILE AMAUROTIC IDIOCY OF THE TAY-SACHS TYPE].

Authors:  E KLENK; U LIEDTKE; W GIELEN
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1963

5.  THE QUANTITATIVE DETERMINATION OF GALACTOSE--AN ENZYMIC METHOD USING GALACTOSE OXIDASE, WITH APPLICATIONS TO BLOOD AND OTHER BIOLOGICAL FLUIDS.

Authors:  H ROTH; S SEGAL; D BERTOLI
Journal:  Anal Biochem       Date:  1965-01       Impact factor: 3.365

6.  [THE ISOLATION OF THE SUGAR PORTION OF GLYCOSPHINGOLIPIDS BY OZONOLYSIS AND FRAGMENTATION].

Authors:  H WIEGANDT; G BASCHANG
Journal:  Z Naturforsch B       Date:  1965-02       Impact factor: 1.047

7.  Structure of main globoside of human erythrocytes.

Authors:  T YAMAKAWA; S YOKOYAMA; N KISO
Journal:  J Biochem       Date:  1962-09       Impact factor: 3.387

8.  The chemical structure of normal human brain and Tay-Sachs gangliosides.

Authors:  L SVENNERHOLM
Journal:  Biochem Biophys Res Commun       Date:  1962-11-27       Impact factor: 3.575

9.  Isolation of beta-galactosidase and beta-glucosidase from brain.

Authors:  S Gatt; M M Rapport
Journal:  Biochim Biophys Acta       Date:  1966-03-07

10.  Enzymic hydrolysis of sphingolipids: Hydrolysis of ceramide glucoside by an enzyme from ox brain.

Authors:  S Gatt
Journal:  Biochem J       Date:  1966-12       Impact factor: 3.857
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  6 in total

1.  Globoid cell leukodystrophy: deficiency of lactosyl ceramide beta-galactosidase.

Authors:  D A Wenger; M Sattler; W Hiatt
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

2.  Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose.

Authors:  Y Fujino; M Nakano
Journal:  Biochem J       Date:  1969-07       Impact factor: 3.857

3.  Enzymic hydrolysis of sphingolipids: Hydrolysis of ceramide glucoside by an enzyme from ox brain.

Authors:  S Gatt
Journal:  Biochem J       Date:  1966-12       Impact factor: 3.857

4.  [Phospholipid metabolism and function of the mammalian brain in vivo. I. Catabolic changes of phospholipids in different parts of the rabbit brain during ischemia].

Authors:  D H Hinzen; W Isselhard; I Füsgen; U Müller
Journal:  Pflugers Arch       Date:  1970       Impact factor: 3.657

5.  Hydrolysis of GM1-ganglioside by human liver beta-galactosidase isoenzymes.

Authors:  M W Ho; P Cheetham; D Robinson
Journal:  Biochem J       Date:  1973-10       Impact factor: 3.857

Review 6.  Ceramide function in the brain: when a slight tilt is enough.

Authors:  Chiara Mencarelli; Pilar Martinez-Martinez
Journal:  Cell Mol Life Sci       Date:  2012-06-24       Impact factor: 9.261
  6 in total

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