Literature DB >> 16741571

IPEX and the role of Foxp3 in the development and function of human Tregs.

Séverine Le Bras1, Raif S Geha.   

Abstract

Genetic defects in the transcription factor forkhead box protein P3 (Foxp3) cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX). IPEX is thought to be due to a defect in naturally arising CD4+ Tregs. In this issue of the JCI, Bacchetta and colleagues demonstrate that patients with IPEX and missense mutations in Foxp3 provide insight into the role of various domains of Foxp3 in the development and function of Tregs (see the related article beginning on page 1713).

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Year:  2006        PMID： 16741571      PMCID： PMC1464917          DOI： 10.1172/JCI28880

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  24 in total

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Journal:  Immunity       Date:  2005-03       Impact factor: 31.745

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Journal:  Nat Immunol       Date:  2003-03-03       Impact factor: 25.606

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Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

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Journal:  J Exp Med       Date:  1998-07-20       Impact factor: 14.307
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  25 in total

1.  2-Gy whole-body irradiation significantly alters the balance of CD4+ CD25- T effector cells and CD4+ CD25+ Foxp3+ T regulatory cells in mice.

Authors:  Yanyan Qu; Baojun Zhang; Shuchun Liu; Aijun Zhang; Tingting Wu; Yong Zhao
Journal:  Cell Mol Immunol       Date:  2010-09-27       Impact factor: 11.530

Review 2.  Tolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for autoimmune diseases.

Authors:  Kevin Hendrawan; Malini Visweswaran; David D F Ma; John J Moore
Journal:  Bone Marrow Transplant       Date:  2019-10-16       Impact factor: 5.483

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Authors:  Runhua Liu; Silin Li; Wei-Hsiung Yang; Lizhong Wang
Journal:  J Syndr       Date:  2013-06

4.  PLA2R-positive (primary) membranous nephropathy in a child with IPEX syndrome.

Authors:  Teresa Chuva; Frederick Pfister; Ortraud Beringer; Kerstin Felgentreff; Maike Büttner-Herold; Kerstin Amann
Journal:  Pediatr Nephrol       Date:  2017-05-09       Impact factor: 3.714

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Authors:  J-E Kim; J-S Shin; J-H Moon; S-W Hong; D-J Jung; J H Kim; I-Y Hwang; Y J Shin; E-Y Gong; D H Lee; S-M Kim; E Y Lee; Y S Kim; D Kim; D Hur; T W Kim; K-P Kim; D-H Jin; W-J Lee
Journal:  Oncogene       Date:  2016-05-30       Impact factor: 9.867

Review 6.  Immunologic endocrine disorders.

Authors:  Aaron W Michels; George S Eisenbarth
Journal:  J Allergy Clin Immunol       Date:  2010-02       Impact factor: 10.793

Review 7.  Autoimmune polyglandular syndromes.

Authors:  Aaron W Michels; Peter A Gottlieb
Journal:  Nat Rev Endocrinol       Date:  2010-03-23       Impact factor: 43.330

Review 8.  CD4 T cells: Balancing the coming and going of autoimmune-mediated inflammation in the CNS.

Authors:  Bonnie N Dittel
Journal:  Brain Behav Immun       Date:  2008-01-18       Impact factor: 7.217

9.  In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesions.

Authors:  Sharvan Sehrawat; Susmit Suvas; Pranita P Sarangi; Amol Suryawanshi; Barry T Rouse
Journal:  J Virol       Date:  2008-05-14       Impact factor: 5.103

10.  Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells.

Authors:  Yvonne Vercoulen; Ellen J Wehrens; Nienke H van Teijlingen; Wilco de Jager; Jeffrey M Beekman; Berent J Prakken
Journal:  PLoS One       Date:  2009-09-25       Impact factor: 3.240
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