Literature DB >> 16740321

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells.

Julie M Johnson-Nauroth1, Jerome Graber, Karen Yao, Steve Jacobson, Peter A Calabresi.   

Abstract

Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Ralpha, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16740321      PMCID： PMC4988392          DOI： 10.1016/j.jneuroim.2006.03.013

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  47 in total

1.  Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP.

Authors:  M Nagai; K Usuku; W Matsumoto; D Kodama; N Takenouchi; T Moritoyo; S Hashiguchi; M Ichinose; C R Bangham; S Izumo; M Osame
Journal:  J Neurovirol       Date:  1998-12       Impact factor: 2.643

2.  Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase.

Authors:  W E Biddison; R Kubota; T Kawanishi; D D Taub; W W Cruikshank; D M Center; E W Connor; U Utz; S Jacobson
Journal:  J Immunol       Date:  1997-08-15       Impact factor: 5.422

3.  Immunologic analysis of a spinal cord-biopsy specimen from a patient with human T-cell lymphotropic virus type I-associated neurologic disease.

Authors:  M C Levin; T J Lehky; A N Flerlage; D Katz; D W Kingma; E S Jaffe; J D Heiss; N Patronas; H F McFarland; S Jacobson
Journal:  N Engl J Med       Date:  1997-03-20       Impact factor: 91.245

4.  HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy.

Authors:  K J Jeffery; K Usuku; S E Hall; W Matsumoto; G P Taylor; J Procter; M Bunce; G S Ogg; K I Welsh; J N Weber; A L Lloyd; M A Nowak; M Nagai; D Kodama; S Izumo; M Osame; C R Bangham
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

5.  Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.

Authors:  S L Cross; M B Feinberg; J B Wolf; N J Holbrook; F Wong-Staal; W J Leonard
Journal:  Cell       Date:  1987-04-10       Impact factor: 41.582

6.  Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis.

Authors:  Nitin J Karandikar; Michael P Crawford; Xiao Yan; Robert B Ratts; Jason M Brenchley; David R Ambrozak; Amy E Lovett-Racke; Elliot M Frohman; Peter Stastny; Daniel C Douek; Richard A Koup; Michael K Racke
Journal:  J Clin Invest       Date:  2002-03       Impact factor: 14.808

7.  Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease.

Authors:  S Jacobson; H Shida; D E McFarlin; A S Fauci; S Koenig
Journal:  Nature       Date:  1990-11-15       Impact factor: 49.962

8.  Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.

Authors:  K Bieganowska; P Höllsberg; G J Buckle; D G Lim; T F Greten; J Schneck; J D Altman; S Jacobson; S L Ledis; B Hanchard; J Chin; O Morgan; P A Roth; D A Hafler
Journal:  J Immunol       Date:  1999-02-01       Impact factor: 5.422

9.  Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease.

Authors:  S Koenig; R M Woods; Y A Brewah; A J Newell; G M Jones; E Boone; J W Adelsberger; M W Baseler; S M Robinson; S Jacobson
Journal:  J Immunol       Date:  1993-10-01       Impact factor: 5.422

10.  Immunological findings in neurological diseases associated with antibodies to HTLV-I: activated lymphocytes in tropical spastic paraparesis.

Authors:  S Jacobson; V Zaninovic; C Mora; P Rodgers-Johnson; W A Sheremata; C J Gibbs; C Gajdusek; D E McFarlin
Journal:  Ann Neurol       Date:  1988       Impact factor: 10.422
View more
  7 in total

1.  Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons.

Authors:  Iris Castro; Teresa M Giret; Diogo M Magnani; Helen S Maxwell; Oliver Umland; Jessica K Perry; Jerilyn K Pecotte; Kathleen M Brasky; Glen N Barber; Ronald C Desrosiers; David I Watkins
Journal:  J Virol       Date:  2016-05-12       Impact factor: 5.103

2.  Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1.

Authors:  Sharrón L Manuel; Mohit Sehgal; John Connolly; George Makedonas; Zafar K Khan; Jay Gardner; Michael R Betts; Pooja Jain
Journal:  J Clin Immunol       Date:  2013-07-26       Impact factor: 8.317

3.  Long-term persistence of limited HTLV-I Tax-specific cytotoxic T cell clones in a patient with adult T cell leukemia/lymphoma after allogeneic stem cell transplantation.

Authors:  Yukie Tanaka; Hideki Nakasone; Rie Yamazaki; Hidenori Wada; Yuko Ishihara; Koji Kawamura; Kana Sakamoto; Masahiro Ashizawa; Tomohito Machishima; Miki Sato; Kiriko Terasako; Shun-ichi Kimura; Misato Kikuchi; Shinya Okuda; Shinichi Kako; Junya Kanda; Aki Tanihara; Junji Nishida; Yoshinobu Kanda
Journal:  J Clin Immunol       Date:  2012-07-05       Impact factor: 8.317

4.  Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis.

Authors:  Raya Massoud; Yoshimi Enose-Akahata; Yutaka Tagaya; Nazli Azimi; Asjad Basheer; Steven Jacobson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-17       Impact factor: 11.205

5.  Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers.

Authors:  Ayako Takamori; Atsuhiko Hasegawa; Atae Utsunomiya; Yasuhiro Maeda; Yoshihisa Yamano; Masato Masuda; Yukiko Shimizu; Yotaro Tamai; Amane Sasada; Na Zeng; Ilseung Choi; Naokuni Uike; Jun Okamura; Toshiki Watanabe; Takao Masuda; Mari Kannagi
Journal:  Retrovirology       Date:  2011-12-07       Impact factor: 4.602

6.  HTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infection.

Authors:  Chibueze Chioma Ezinne; Makoto Yoshimitsu; Yohann White; Naomichi Arima
Journal:  PLoS One       Date:  2014-02-05       Impact factor: 3.240

Review 7.  Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection.

Authors:  Marcia Bellon; Christophe Nicot
Journal:  Viruses       Date:  2017-10-05       Impact factor: 5.048
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.