BACKGROUND: The aim of this study was to assess the efficacy and safety of targeted radionuclide therapy with [90Y-DOTA0, Tyr3]-octreotide (90Y-DOTATOC) in patients with metastatic neuroendocrine tumors. PATIENTS AND METHODS: One hundred and sixteen patients with metastatic neuroendocrine tumors were included. All patients were pre-therapeutically staged with morphological imaging procedures and with somatostatin receptor scintigraphy. The scintigraphy was positive in all cases. The patients were treated with 162-200 mCi/m2 body surface. In 57 patients, the quality of life was assessed with the National Cancer Institute grading criteria (NCI-CTC). Restaging was performed 8-12 weeks after the last treatment cycle. Blood samples were drawn every 2 weeks after the treatment to evaluate toxicity. RESULTS: Complete remissions were found in 4%, partial remissions in 23%, stabilization in 62% and progressive disease in 11%. A significant reduction of symptoms was found in 83%. No serious adverse event occurred and the toxicity was acceptable. CONCLUSION: 90Y-DOTATOC is a safe and effective treatment for patients with metastatic neuroendocrine tumors.
BACKGROUND: The aim of this study was to assess the efficacy and safety of targeted radionuclide therapy with [90Y-DOTA0, Tyr3]-octreotide (90Y-DOTATOC) in patients with metastatic neuroendocrine tumors. PATIENTS AND METHODS: One hundred and sixteen patients with metastatic neuroendocrine tumors were included. All patients were pre-therapeutically staged with morphological imaging procedures and with somatostatin receptor scintigraphy. The scintigraphy was positive in all cases. The patients were treated with 162-200 mCi/m2 body surface. In 57 patients, the quality of life was assessed with the National Cancer Institute grading criteria (NCI-CTC). Restaging was performed 8-12 weeks after the last treatment cycle. Blood samples were drawn every 2 weeks after the treatment to evaluate toxicity. RESULTS: Complete remissions were found in 4%, partial remissions in 23%, stabilization in 62% and progressive disease in 11%. A significant reduction of symptoms was found in 83%. No serious adverse event occurred and the toxicity was acceptable. CONCLUSION: 90Y-DOTATOC is a safe and effective treatment for patients with metastatic neuroendocrine tumors.
Authors: Constantin Lapa; Rudolf A Werner; Christina Bluemel; Katharina Lückerath; Andreas Schirbel; Alexander Strate; Andreas K Buck; Ken Herrmann Journal: EJNMMI Res Date: 2014-08-23 Impact factor: 3.138
Authors: Eric W Price; Kimberly J Edwards; Kathryn E Carnazza; Sean D Carlin; Brian M Zeglis; Michael J Adam; Chris Orvig; Jason S Lewis Journal: Nucl Med Biol Date: 2016-06-28 Impact factor: 2.408
Authors: W Barry Edwards; Baogang Xu; Walter Akers; Philip P Cheney; Kexian Liang; Buck E Rogers; Carolyn J Anderson; Samuel Achilefu Journal: Bioconjug Chem Date: 2007-11-20 Impact factor: 4.774