BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies in Western countries. One major event during CRC development is loss of genetic material on chromosome 18, on which the smad4/dpc4 gene is located. SMAD4 is an important mediator of intracellular signaling in the TGF-beta pathway. The functional inactivation of SMAD4 has been reported to occur in CRC. MATERIALS AND METHOD: The protein expression of SMAD4 was evaluated immunohistochemically in 86 formalin-fixed and paraffin-embedded CRC samples. The results were related to clinicopathological variables including survival. RESULTS: The loss of nuclear SMAD4 protein expression was observed in 9.3% of the investigated CRCs and was correlated to poor prognosis in univariate Kaplan-Meier (p=0.034) as well as in multivariate Cox-regression (p=0.028) analyses. CONCLUSION: The loss of nuclear SMAD4 protein expression occurs in a subset of CRC and is associated with poor prognosis.
BACKGROUND:Colorectal cancer (CRC) is one of the most common malignancies in Western countries. One major event during CRC development is loss of genetic material on chromosome 18, on which the smad4/dpc4 gene is located. SMAD4 is an important mediator of intracellular signaling in the TGF-beta pathway. The functional inactivation of SMAD4 has been reported to occur in CRC. MATERIALS AND METHOD: The protein expression of SMAD4 was evaluated immunohistochemically in 86 formalin-fixed and paraffin-embedded CRC samples. The results were related to clinicopathological variables including survival. RESULTS: The loss of nuclear SMAD4 protein expression was observed in 9.3% of the investigated CRCs and was correlated to poor prognosis in univariate Kaplan-Meier (p=0.034) as well as in multivariate Cox-regression (p=0.028) analyses. CONCLUSION: The loss of nuclear SMAD4 protein expression occurs in a subset of CRC and is associated with poor prognosis.
Authors: Upender Manne; Chandrakumar Shanmugam; Venkat R Katkoori; Harvey L Bumpers; William E Grizzle Journal: Cancer Biomark Date: 2010 Impact factor: 4.388
Authors: Tanner J Freeman; J Joshua Smith; Xi Chen; M Kay Washington; Joseph T Roland; Anna L Means; Steven A Eschrich; Timothy J Yeatman; Natasha G Deane; R Daniel Beauchamp Journal: Gastroenterology Date: 2011-11-22 Impact factor: 22.682
Authors: S G Royce; K Alsop; A Haydon; L Mead; L D Smith; A A Tesoriero; G G Giles; M A Jenkins; J L Hopper; M C Southey Journal: Colorectal Dis Date: 2009-01-27 Impact factor: 3.788
Authors: Sabine Tejpar; Monica Bertagnolli; Fred Bosman; Heinz-Joseph Lenz; Levi Garraway; Frederic Waldman; Robert Warren; Andrea Bild; Denise Collins-Brennan; Hejin Hahn; D Paul Harkin; Richard Kennedy; Mohammad Ilyas; Hans Morreau; Vitali Proutski; Charles Swanton; Ian Tomlinson; Mauro Delorenzi; Roberto Fiocca; Eric Van Cutsem; Arnaud Roth Journal: Oncologist Date: 2010-03-29