Johan Agren1, Gunnar Sjörs, Gunnar Sedin. 1. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. johan.agren@kbh.uu.se
Abstract
OBJECTIVES: To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might influence their postnatal skin maturation. STUDY DESIGN: In 22 preterm infants (GA 23-27 weeks), transepidermal water loss (TEWL) was determined at postnatal ages (PNA) of 0, 3, 7, 14, and 28 days. At a PNA of 7 days, the infants were randomized to care at either 50% or 75% RH. RESULTS:TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days, TEWL was about twice as high in infants nursed at 75% RH (22 +/- 2 g/m2 h) than in those nursed at 50% RH (13 +/- 1 g/m2 h; P < .001). CONCLUSIONS: The results indicate that the level of RH influences skin barrier development, with more rapid barrier formation in infants nursed at a lower RH. The findings have an impact on strategies for promoting skin barrier integrity in extremely preterm infants.
RCT Entities:
OBJECTIVES: To test the hypothesis that the level of relative humidity (RH) in which preterm infants are nursed might influence their postnatal skin maturation. STUDY DESIGN: In 22 preterm infants (GA 23-27 weeks), transepidermal water loss (TEWL) was determined at postnatal ages (PNA) of 0, 3, 7, 14, and 28 days. At a PNA of 7 days, the infants were randomized to care at either 50% or 75% RH. RESULTS: TEWL decreased at a slower rate in infants nursed at the higher RH. At a PNA of 28 days, TEWL was about twice as high in infants nursed at 75% RH (22 +/- 2 g/m2 h) than in those nursed at 50% RH (13 +/- 1 g/m2 h; P < .001). CONCLUSIONS: The results indicate that the level of RH influences skin barrier development, with more rapid barrier formation in infants nursed at a lower RH. The findings have an impact on strategies for promoting skin barrier integrity in extremely preterm infants.
Authors: Richard Sun; Anna Celli; Debra Crumrine; Melanie Hupe; Lillian C Adame; Sally D Pennypacker; Kyungho Park; Yoshikazu Uchida; Kenneth R Feingold; Peter M Elias; Dusko Ilic; Theodora M Mauro Journal: Tissue Eng Part C Methods Date: 2015-01 Impact factor: 3.056
Authors: Laura Cau; Valérie Pendaries; Emeline Lhuillier; Paul R Thompson; Guy Serre; Hidenari Takahara; Marie-Claire Méchin; Michel Simon Journal: J Dermatol Sci Date: 2017-02-20 Impact factor: 4.563
Authors: Marty O Visscher; Andrew N Carr; Jason Winget; Thomas Huggins; Charles C Bascom; Robert Isfort; Karen Lammers; Vivek Narendran Journal: Pediatr Res Date: 2020-06-29 Impact factor: 3.756
Authors: Matthew A Rysavy; Katrin Mehler; André Oberthür; Johan Ågren; Satoshi Kusuda; Patrick J McNamara; Regan E Giesinger; Angela Kribs; Erik Normann; Susan J Carlson; Jonathan M Klein; Carl H Backes; Edward F Bell Journal: J Pediatr Date: 2021-03-07 Impact factor: 6.314
Authors: Tina Lavender; Carol Bedwell; Stephen A Roberts; Anna Hart; Mark A Turner; Lesley-Anne Carter; Michael J Cork Journal: J Obstet Gynecol Neonatal Nurs Date: 2013-02-19