Literature DB >> 16737321

Antimalarial activity of a new family of analogues of manzamine A.

Jeffrey D Winkler1, Allyn T Londregan, Mark T Hamann.   

Abstract

Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies. The synthesis and biological evaluation of a group of simplified analogues of manzamine A, which were designed to examine the roles of the A and D rings and of both the relative stereochemistry and the orientation of the beta-carboline heterocycle on the antimalarial activity of manzamine A, are described. [structure: see text]

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Year:  2006        PMID： 16737321      PMCID： PMC4918909          DOI： 10.1021/ol060848d

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

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