Literature DB >> 1673626

Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose.

R A Henderson1, S Lane, J A Henry.   

Abstract

A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventional anti-arrhythmic therapy but was suppressed by atrial overdrive pacing. A literature review identified haloperidol as the most likely cause of the torsades de pointes.

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Year:  1991        PMID： 1673626     DOI： 10.1177/096032719101000110

Source DB:  PubMed          Journal:  Hum Exp Toxicol        ISSN： 0960-3271            Impact factor:   2.903


  8 in total

Review 1.  Pharmacokinetic factors in the adverse cardiovascular effects of antipsychotic drugs.

Authors:  Candace S Brown; Richard G Farmer; Judith E Soberman; Samantha F Eichner
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Review 2.  Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death.

Authors:  Karine Titier; Pierre-Olivier Girodet; Hélène Verdoux; Mathieu Molimard; Bernard Bégaud; Wilhelm Haverkamp; Malcolm Lader; Nicholas Moore
Journal:  Drug Saf       Date:  2005       Impact factor: 5.606

3.  Torsade de pointes after pipamperone intoxication.

Authors:  L Bont; H A Bosker; F Brus; J P Yska; F H Bosch
Journal:  Pharm World Sci       Date:  1998-06

Review 4.  Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?

Authors:  Pal Pacher; Valeria Kecskemeti
Journal:  Curr Pharm Des       Date:  2004       Impact factor: 3.116

Review 5.  Antipsychotic-related QTc prolongation, torsade de pointes and sudden death.

Authors:  Peter M Haddad; Ian M Anderson
Journal:  Drugs       Date:  2002       Impact factor: 9.546

6.  Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.

Authors:  Eberhard P Scholz; Franziska M Konrad; Daniel L Weiss; Edgar Zitron; Claudia Kiesecker; Ramona Bloehs; Martin Kulzer; Dierk Thomas; Sven Kathöfer; Alexander Bauer; Martin H Maurer; Gunnar Seemann; Hugo A Katus; Christoph A Karle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-10-27       Impact factor: 3.000

7.  An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia.

Authors:  Stefan Dhein; Franziska Perlitz; Friedrich-Wilhelm Mohr
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-07-22       Impact factor: 3.000

8.  Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome.

Authors:  Alexander Bauer; J Kevin Donahue; Frederik Voss; Ruediger Becker; Patricia Kraft; Julia C Senges; Kamilla Kelemen; Hugo A Katus; Wolfgang Schoels
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-02-19       Impact factor: 3.000
  8 in total

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