| Literature DB >> 16735105 |
Cigdem Gelegen1, David A Collier, Iain C Campbell, Hugo Oppelaar, José van den Heuvel, Roger A H Adan, Martien J H Kas.
Abstract
Food restricted rodents develop activity-based anorexia in the presence of a running wheel, characterised by increased physical activity, weight loss and decreased leptin levels. Here, we determined trait differences in the development of activity-based anorexia between C57BL/6J and DBA/2J inbred mouse lines previously reported as having low and high anxiety, respectively. C57BL/6J mice housed with running wheels and exposed to scheduled feeding reduced their wheel activity, in contrast to DBA/2J mice which exhibited increased behavioural activity under these conditions. Food restriction induced hypoleptinemia in both strains, but the decline in plasma leptin was stronger in DBA/2J mice and correlated with increased activity only in that strain. These data suggest that plasma leptin level dynamics rather than hypoleptinemia alone influences the development of activity-based anorexia and that recombinant inbred panels based on these progenitor lines offer opportunities for the identification of molecular determinants for anorexia nervosa related behavioural traits.Entities:
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Year: 2006 PMID： 16735105 DOI： 10.1016/j.euroneuro.2006.04.007
Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600