PURPOSE: This pilot study investigated if scaling and root planing (S&RP) was an effective intervention in reducing levels of inflammatory markers TNF-alpha and IL-6 in a type 2 diabetic population. METHODS: Twenty-five patients with type 2 diabetes, 18-64 years of age were enrolled having 4 or more sites with pocket depths > or = 5mm and 2 or more sites with attachment loss > or = 3mm. Participants received S&RP following collection of gingival crevicular fluid and serum which were analyzed for TNF-alpha and IL-6. After 3 months post-treatment levels were collected. Serum pre-and post-treatment levels were analyzed using a paired t test at a significance level of p < or = 0.05. Mean TNF-alpha was 1.7 pg/ml at baseline and post-treatment was 4.0 pg/ml. Mean IL-6 was 2.8 pg/ml at baseline and post-treatment 6.0 pg/ml. RESULTS: Both mean TNF-alpha and IL-6 were increased following S&RP ; however, the observed increases were not statistically significant. While participants improved on periodontal measures following therapy, systemic measures of inflammation (TNF-alpha and IL-6) did not show the hypothesized reductions. CONCLUSION: Further studies are needed to determine effectiveness of S&RP on inflammatory mediators in a population with type 2 diabetes.
PURPOSE: This pilot study investigated if scaling and root planing (S&RP) was an effective intervention in reducing levels of inflammatory markers TNF-alpha and IL-6 in a type 2 diabetic population. METHODS: Twenty-five patients with type 2 diabetes, 18-64 years of age were enrolled having 4 or more sites with pocket depths > or = 5mm and 2 or more sites with attachment loss > or = 3mm. Participants received S&RP following collection of gingival crevicular fluid and serum which were analyzed for TNF-alpha and IL-6. After 3 months post-treatment levels were collected. Serum pre-and post-treatment levels were analyzed using a paired t test at a significance level of p < or = 0.05. Mean TNF-alpha was 1.7 pg/ml at baseline and post-treatment was 4.0 pg/ml. Mean IL-6 was 2.8 pg/ml at baseline and post-treatment 6.0 pg/ml. RESULTS: Both mean TNF-alpha and IL-6 were increased following S&RP ; however, the observed increases were not statistically significant. While participants improved on periodontal measures following therapy, systemic measures of inflammation (TNF-alpha and IL-6) did not show the hypothesized reductions. CONCLUSION: Further studies are needed to determine effectiveness of S&RP on inflammatory mediators in a population with type 2 diabetes.
Authors: Hilana Paula Carillo Artese; Adriana Moura Foz; Mariana de Sousa Rabelo; Giovane Hisse Gomes; Marco Orlandi; Jean Suvan; Francesco D'Aiuto; Giuseppe Alexandre Romito Journal: PLoS One Date: 2015-05-26 Impact factor: 3.240
Authors: Fabienne A Gerber; Philipp Sahrmann; Oliver A Schmidlin; Christian Heumann; Jürg Hans Beer; Patrick R Schmidlin Journal: BMC Oral Health Date: 2016-09-02 Impact factor: 2.757