Literature DB >> 16733586

Carbohydrate triazoles and isoxazoles as inhibitors of galectins-1 and -3.

Denis Giguère1, Ramesh Patnam, Marc-André Bellefleur, Christian St-Pierre, Sachiko Sato, René Roy.   

Abstract

Galactosides and lactosides bearing triazoles or isoxazoles, regiospecifically prepared by [1,3]-dipolar cycloadditions between alkynes, azides or nitrile oxides, provided specific galectin-1 and -3 inhibitors with potencies as low as 20 microM.

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Year:  2006        PMID： 16733586     DOI： 10.1039/b517529a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Galectin-1-specific inhibitors as a new class of compounds to treat HIV-1 infection.

Authors:  Christian St-Pierre; Michel Ouellet; Denis Giguère; Reiko Ohtake; René Roy; Sachiko Sato; Michel J Tremblay
Journal:  Antimicrob Agents Chemother       Date:  2011-11-07       Impact factor: 5.191

Review 2.  Design and creativity in synthesis of multivalent neoglycoconjugates.

Authors:  Yoann M Chabre; René Roy
Journal:  Adv Carbohydr Chem Biochem       Date:  2010       Impact factor: 12.200

Review 3.  Synthetic glycoconjugates inhibitors of tumor-related galectin-3: an update.

Authors:  Vanessa Leiria Campo; Marcelo Fiori Marchiori; Lílian Cataldi Rodrigues; Marcelo Dias-Baruffi
Journal:  Glycoconj J       Date:  2016-08-15       Impact factor: 2.916

4.  Crystallization and preliminary crystallographic analysis of recombinant human galectin-1.

Authors:  Stacy A Scott; Ken Scott; Helen Blanchard
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-10-24

5.  'Click chemistry' synthesis of 1-(α-D-mannopyranosyl)-1,2,3-triazoles for inhibition of α-mannosidases.

Authors:  Monika Poláková; Rhiannon Stanton; Iain B H Wilson; Ivana Holková; Sergej Šesták; Eva Machová; Zuzana Jandová; Juraj Kóňa
Journal:  Carbohydr Res       Date:  2015-01-19       Impact factor: 2.104

Review 6.  Galectins as Molecular Targets for Therapeutic Intervention.

Authors:  Ruud P M Dings; Michelle C Miller; Robert J Griffin; Kevin H Mayo
Journal:  Int J Mol Sci       Date:  2018-03-19       Impact factor: 5.923

7.  Hybrid ligands with calixarene and thiodigalactoside groups: galectin binding and cytotoxicity.

Authors:  Hao Zhang; Hans Ippel; Michelle C Miller; Tse J Wong; Arjan W Griffioen; Kevin H Mayo; Roland J Pieters
Journal:  Org Chem Front       Date:  2019-07-12       Impact factor: 5.281

8.  Synthesis of new triazole-based trifluoromethyl scaffolds.

Authors:  Michela Martinelli; Thierry Milcent; Sandrine Ongeri; Benoit Crousse
Journal:  Beilstein J Org Chem       Date:  2008-05-29       Impact factor: 2.883

9.  Synthesis and solvodynamic diameter measurements of closely related mannodendrimers for the study of multivalent carbohydrate-protein interactions.

Authors:  Yoann M Chabre; Alex Papadopoulos; Alexandre A Arnold; René Roy
Journal:  Beilstein J Org Chem       Date:  2014-07-04       Impact factor: 2.883
  9 in total

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