Literature DB >> 16733577

Are branched chain fatty acids the natural substrates for P450(BM3)?

Max J Cryle1, Rocio D Espinoza, Sarah J Smith, Nicholas J Matovic, James J De Voss.   

Abstract

Branched chain fatty acids are substrates for cytochrome P450(BM3) (CYP102) from Bacillus megaterium; oxidation of C15 and C17 iso and anteiso fatty acids by P450(BM3) leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity.

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Year:  2006        PMID： 16733577     DOI： 10.1039/b601202g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Chain length-dependent cooperativity in fatty acid binding and oxidation by cytochrome P450BM3 (CYP102A1).

Authors:  Benjamin Rowlatt; Jake A Yorke; Anthony J Strong; Christopher J C Whitehouse; Stephen G Bell; Luet-Lok Wong
Journal:  Protein Cell       Date:  2011-09-09       Impact factor: 14.870

2.  Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation.

Authors:  Yu Yan; Jing Wu; Guipeng Hu; Cong Gao; Liang Guo; Xiulai Chen; Liming Liu; Wei Song
Journal:  Synth Syst Biotechnol       Date:  2022-05-08

3.  Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution.

Authors:  Jesse D Bloom; Philip A Romero; Zhongyi Lu; Frances H Arnold
Journal:  Biol Direct       Date:  2007-06-28       Impact factor: 4.540
  3 in total

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