D A Lozsadi1, A J Larner. 1. Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
Abstract
BACKGROUND/AIMS: To investigate the frequency of epilepsy at the time of diagnosis of Alzheimer's disease (AD). METHODS: Observational study, Cognitive Function Clinic population, over a 6-year period (2000-2005 inclusive). RESULTS: In a cohort of 177 patients with newly diagnosed clinically probable AD, 12 (6.8%) had a history of seizure disorder and/or were using anti-epileptic medications at the time of diagnosis. In 6 of these cases (3.4%), seizure onset was approximately concurrent with the onset of cognitive decline, and no symptomatic or provoking factor for seizures other than AD was identified. CONCLUSION: Although epileptic seizures are more common later in the course of AD, nonetheless they may accompany the onset of, and be symptomatic of, the disease, perhaps reflecting a shared pathogenesis. Copyright (c) 2006 S. Karger AG, Basel.
BACKGROUND/AIMS: To investigate the frequency of epilepsy at the time of diagnosis of Alzheimer's disease (AD). METHODS: Observational study, Cognitive Function Clinic population, over a 6-year period (2000-2005 inclusive). RESULTS: In a cohort of 177 patients with newly diagnosed clinically probable AD, 12 (6.8%) had a history of seizure disorder and/or were using anti-epileptic medications at the time of diagnosis. In 6 of these cases (3.4%), seizure onset was approximately concurrent with the onset of cognitive decline, and no symptomatic or provoking factor for seizures other than AD was identified. CONCLUSION: Although epileptic seizures are more common later in the course of AD, nonetheless they may accompany the onset of, and be symptomatic of, the disease, perhaps reflecting a shared pathogenesis. Copyright (c) 2006 S. Karger AG, Basel.
Authors: Alexander J Beagle; Sonja M Darwish; Kamalini G Ranasinghe; Alice L La; Elissaios Karageorgiou; Keith A Vossel Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Brian F Corbett; Jason C You; Xiaohong Zhang; Mark S Pyfer; Umberto Tosi; Daniel M Iascone; Iraklis Petrof; Anupam Hazra; Chia-Hsuan Fu; Gabriel S Stephens; Annie A Ashok; Suzan Aschmies; Lijuan Zhao; Eric J Nestler; Jeannie Chin Journal: Cell Rep Date: 2017-07-11 Impact factor: 9.423