| Literature DB >> 16731012 |
Mao Chen1, Zhong-Cai Fan, Xiao-Jing Liu, Jue-Lin Deng, Li Zhang, Li Rao, Qing Yang, De-Jia Huang.
Abstract
To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16731012 DOI： 10.1016/j.cellbi.2006.03.002
Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612