| Literature DB >> 16730987 |
R R Wilkening1, R W Ratcliffe, A K Fried, D Meng, W Sun, L Colwell, S Lambert, M Greenlee, S Nilsson, A Thorsell, M Mojena, C Tudela, K Frisch, W Chan, E T Birzin, S P Rohrer, M L Hammond.
Abstract
Synthesis of a series of fused pyrazole tetrahydrofluorenone analogs which are potent, ERbeta subtype selective ligands is described. Analogs possessing subnanomolar ERbeta binding, greater than 100-fold ERbeta-selectivity, and oral bioavailability are reported.Entities:
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Year: 2006 PMID： 16730987 DOI： 10.1016/j.bmcl.2006.05.036
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823