Literature DB >> 16730804

Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis.

Maria A Staykova1, Susan A Fordham, Gavin J Bartell, William B Cowden, David O Willenborg.   

Abstract

EAE development in SJL/J mice is age and sex dependent: young males are EAE resistant; females and adult males are EAE susceptible. By studying splenocytes' IFNgamma and NO production and the induction or the suppression of actively induced EAE by manipulating NO systemic levels, we provide evidence that the failure of young male SJL/J mice to develop EAE lies in the activation of the innate immune system by the immunising stimulus.

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Year:  2006        PMID： 16730804     DOI： 10.1016/j.jneuroim.2006.03.015

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  3 in total

1.  Gender-specific expression of beta1 integrin of VLA-4 in myelin basic protein-primed T cells: implications for gender bias in multiple sclerosis.

Authors:  Saurav Brahmachari; Kalipada Pahan
Journal:  J Immunol       Date:  2010-05-05       Impact factor: 5.422

2.  Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis.

Authors:  Chithra D Palani; Abdelrahman Y Fouda; Fang Liu; Zhimin Xu; Eslam Mohamed; Shailedra Giri; Sylvia B Smith; Ruth B Caldwell; S Priya Narayanan
Journal:  Mol Neurobiol       Date:  2019-07-06       Impact factor: 5.590

3.  Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice.

Authors:  Karen M Spach; Melissa Blake; Janice Y Bunn; Ben McElvany; Rajkumar Noubade; Elizabeth P Blankenhorn; Cory Teuscher
Journal:  J Immunol       Date:  2009-02-15       Impact factor: 5.422
  3 in total

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