| Literature DB >> 16730442 |
Abstract
The key viral gene responsible for initiating the replicative cycle of Epstein-Barr virus (EBV), termed BZLF1, encodes the multifunctional protein Zta (ZEBRA or Z). It interacts with DNA as both a transcription and a replication factor, modulates both intracellular signal transduction and the DNA-damage response and manipulates cell cycle progression. Muller and colleagues have resolved the structure of Zta bound to DNA, which confirms some structural predictions but reveals an unexpected twist and a complex dimerization interface. Because EBV is associated with human disease, Zta presents a prime target for drug design.Entities:
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Year: 2006 PMID： 16730442 PMCID： PMC4221735 DOI： 10.1016/j.tim.2006.05.003
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079