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Literature DB >> 16730027

A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact.

Stephen Hare¹, Richard Bayliss, Christian Baron, Gabriel Waksman.

Abstract

VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits.

Entities: Gene Species

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Year: 2006 PMID： 16730027 DOI： 10.1016/j.jmb.2006.04.060

Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469

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Cited

39 in total

Review 1. Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.

Authors: David G Thanassi; James B Bliska; Peter J Christie
Journal: FEMS Microbiol Rev Date: 2012-05-24 Impact factor: 16.408

2. Regulation of the type IV secretion ATPase TrwD by magnesium: implications for catalytic mechanism of the secretion ATPase superfamily.

Authors: Jorge Ripoll-Rozada; Alejandro Peña; Susana Rivas; Fernando Moro; Fernando de la Cruz; Elena Cabezón; Ignacio Arechaga
Journal: J Biol Chem Date: 2012-03-30 Impact factor: 5.157

A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact.

Review 1. Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.

2. Regulation of the type IV secretion ATPase TrwD by magnesium: implications for catalytic mechanism of the secretion ATPase superfamily.

3. Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system.

4. PilB and PilT are ATPases acting antagonistically in type IV pilus function in Myxococcus xanthus.

Review 5. Mechanism and structure of the bacterial type IV secretion systems.

6. Functional interactions of VirB11 traffic ATPases with VirB4 and VirD4 molecular motors in type IV secretion systems.

7. Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation.

Review 8. Biological diversity of prokaryotic type IV secretion systems.

9. Structure and mechanism of the lipooligosaccharide sialyltransferase from Neisseria meningitidis.

10. An anomalous type IV secretion system in Rickettsia is evolutionarily conserved.