Literature DB >> 16729724

Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline.

Changhai Ding1, Graeme Jones.   

Abstract

Belimumab, the lead in a series of human monoclonal antibodies against the human protein B-lymphocyte stimulator (BLyS), is under development by Human Genome Sciences, Cambridge Antibody Technology and GlaxoSmithKline for the potential treatment of autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year.

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Year:  2006        PMID: 16729724

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN: 1472-4472


  9 in total

Review 1.  Notes on the kidney and its diseases for the neurologist.

Authors:  Michael S Zandi; Alasdair J Coles
Journal:  J Neurol Neurosurg Psychiatry       Date:  2007-05       Impact factor: 10.154

2.  Contemporary treatment of systemic lupus erythematosus: an update for clinicians.

Authors:  Maame B Amissah-Arthur; Caroline Gordon
Journal:  Ther Adv Chronic Dis       Date:  2010-07       Impact factor: 5.091

Review 3.  Manipulating B cell homeostasis: a key component in the advancement of targeted strategies.

Authors:  Laura S Treml; William J Quinn; John F Treml; Jean L Scholz; Michael P Cancro
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2008-05-30       Impact factor: 4.291

4.  In vivo BLyS/BAFF neutralization ameliorates islet-directed autoimmunity in nonobese diabetic mice.

Authors:  Ghazal Zekavat; Susan Y Rostami; Armen Badkerhanian; Ronald F Parsons; Brigitte Koeberlein; Ming Yu; Christopher D Ward; Thi-Sau Migone; Liping Yu; George S Eisenbarth; Michael P Cancro; Ali Naji; Hooman Noorchashm
Journal:  J Immunol       Date:  2008-12-01       Impact factor: 5.422

Review 5.  Cracking the BAFF code.

Authors:  Fabienne Mackay; Pascal Schneider
Journal:  Nat Rev Immunol       Date:  2009-07       Impact factor: 53.106

6.  B-cell tolerance in transplantation: is repertoire remodeling the answer?

Authors:  Ronald F Parsons; Kumar Vivek; Robert R Redfield; Thi-Sau Migone; Michael P Cancro; Ali Naji; Hooman Noorchashm
Journal:  Expert Rev Clin Immunol       Date:  2009-11       Impact factor: 4.473

Review 7.  The potential utility of B cell-directed biologic therapy in autoimmune diseases.

Authors:  D G Arkfeld
Journal:  Rheumatol Int       Date:  2007-10-24       Impact factor: 2.631

8.  An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus.

Authors:  C Pena-Rossi; E Nasonov; M Stanislav; V Yakusevich; O Ershova; N Lomareva; H Saunders; J Hill; I Nestorov
Journal:  Lupus       Date:  2009-05       Impact factor: 2.911

9.  Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint.

Authors:  Lakhvir K Assi; See Heng Wong; Andreas Ludwig; Karim Raza; Caroline Gordon; Michael Salmon; Janet M Lord; Dagmar Scheel-Toellner
Journal:  Arthritis Rheum       Date:  2007-06
  9 in total

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