Literature DB >> 16725322

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors.

Chamakura V N S Varaprasad1, Dinesh Barawkar, Hassan El Abdellaoui, Subrata Chakravarty, Matthew Allan, Huanming Chen, Weijian Zhang, Jim Z Wu, Robert Tam, Robert Hamatake, Stanley Lang, Zhi Hong.   

Abstract

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.

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Year:  2006        PMID： 16725322     DOI： 10.1016/j.bmcl.2006.05.019

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis, fungicidal evaluation and 3D-QSAR studies of novel 1,3,4-thiadiazole xylofuranose derivatives.

Authors:  Guanghui Zong; Xiaojing Yan; Jiawei Bi; Rui Jiang; Yinan Qin; Huizhu Yuan; Huizhe Lu; Yanhong Dong; Shuhui Jin; Jianjun Zhang
Journal:  PLoS One       Date:  2017-07-26       Impact factor: 3.240

2.  Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy.

Authors:  Todd Bosanac; Robert O Hughes; Thomas Engber; Rajesh Devraj; Andrew Brearley; Kerstin Danker; Kenneth Young; Jens Kopatz; Melanie Hermann; Antoine Berthemy; Susan Boyce; Jonathan Bentley; Raul Krauss
Journal:  Brain       Date:  2021-11-29       Impact factor: 13.501
  2 in total

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