| Literature DB >> 16725125 |
Xiaoqun Zhang1, Per E Andren, Per Svenningsson.
Abstract
The subthalamic nucleus and the striatum are input regions of the basal ganglia. This study used the unilateral 6-OHDA rat model of Parkinson's disease to examine effects of l-DOPA on the expression of c-fos and BDNF mRNAs in these nuclei. Dopamine depletion per se did not affect c-fos or BDNF. Both a single and repeated injections of l-DOPA induced c-fos, but not BDNF, in the dopamine-depleted striatum. However, repeated l-DOPA treatment increased c-fos and BDNF in the dopamine-depleted subthalamic nucleus. These molecular adaptations may reflect changes in neuronal plasticity that underlie some therapeutic actions and/or side effects of l-DOPA in Parkinson's disease.Entities:
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Year: 2006 PMID： 16725125 DOI： 10.1016/j.brainres.2006.04.019
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252