Literature DB >> 16724845

Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp.

George R Pettit1, Jiang Du, Robin K Pettit, Linda A Richert, Fiona Hogan, Venugopal J R V Mukku, Michael S Hoard.   

Abstract

A Streptomyces sp. isolated from riverbank soil in Manitoba, Canada, was found to contain two cancer cell growth inhibitories: diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8). The structures were determined by interpretation of data from HRMS, UV, and high-field (400 MHz) NMR experiments. The red-colored diazaanthraquinone 1 and 3-(hydroxyacetyl)indole (8) were found to inhibit (0.1-3 microg/mL) growth of a minipanel of human cancer cell lines and P388 lymphocytic leukemia cells. Diazaanthraquinone 1 was also found to inhibit growth of the bacteria Streptococcus pneumoniae and Neisseria gonorrheae. However, three companion constituents, cyclo-Pro-Leu (5), cyclo-Pro-Phe (6), and cyclo-Pro-Val (7), did not inhibit cancer cell growth.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16724845     DOI： 10.1021/np058087v

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.

Authors:  Jana Braesel; Jung-Ho Lee; Benoit Arnould; Brian T Murphy; Alessandra S Eustáquio
Journal:  J Nat Prod       Date:  2019-03-21       Impact factor: 4.050

2.  Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis.

Authors:  Igor V Magedov; Madhuri Manpadi; Nikolai M Evdokimov; Eerik M Elias; Elena Rozhkova; Marcia A Ogasawara; Jennifer D Bettale; Nikolai M Przheval'skii; Snezna Rogelj; Alexander Kornienko
Journal:  Bioorg Med Chem Lett       Date:  2007-05-06       Impact factor: 2.823

3.  Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces.

Authors:  Xiachang Wang; Sherif I Elshahawi; Larissa V Ponomareva; Qing Ye; Yang Liu; Gregory C Copley; James C Hower; Bruce E Hatcher; Madan K Kharel; Steven G Van Lanen; Qing-Bai She; S Randal Voss; Jon S Thorson; Khaled A Shaaban
Journal:  J Nat Prod       Date:  2019-12-13       Impact factor: 4.050

4.  β-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGF-β/Smad Signaling Pathway.

Authors:  Meng-Jiao Hao; Pei-Nan Chen; Hou-Jin Li; Feng Wu; Guang-Yu Zhang; Zong-Ze Shao; Xiu-Pian Liu; Wen-Zhe Ma; Jun Xu; Taifo Mahmud; Wen-Jian Lan
Journal:  Front Microbiol       Date:  2022-07-28       Impact factor: 6.064
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.