Literature DB >> 1672390

Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation.

G Remuzzi1, M Rossini, O Imberti, N Perico.   

Abstract

Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT1(1] rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2.5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT1(1] rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.

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Year:  1991        PMID： 1672390     DOI： 10.1016/0140-6736(91)91368-5

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  14 in total

1.  Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow.

Authors:  J S Odorico; T O'Connor; L Campos; C F Barker; A M Posselt; A Naji
Journal:  Ann Surg       Date:  1993-10       Impact factor: 12.969

2.  Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides.

Authors:  G Remuzzi; M Noris; A Benigni; O Imberti; M H Sayegh; N Perico
Journal:  J Exp Med       Date:  1994-11-01       Impact factor: 14.307

3.  Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat.

Authors:  E Kobayashi; N Kamada; L Delriviere; R Lord; S Goto; N I Walker; S Enosawa; M Miyata
Journal:  Immunology       Date:  1995-02       Impact factor: 7.397

4.  Differential effects of oral versus intrathymic administration of polymorphic major histocompatibility complex class II peptides on mononuclear and endothelial cell activation and cytokine expression during a delayed-type hypersensitivity response.

Authors:  W W Hancock; S J Khoury; C B Carpenter; M H Sayegh
Journal:  Am J Pathol       Date:  1994-06       Impact factor: 4.307

5.  An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis.

Authors:  A M Salmon; C Bruand; A Cardona; J P Changeux; S Berrih-Aknin
Journal:  J Clin Invest       Date:  1998-06-01       Impact factor: 14.808

6.  Longer transplanted heart allograft survival in rats without immunosuppressants after intrathymic myocardial cell inoculation in the neonatal period.

Authors:  K Seo; S Imamura; Y Ohta; T Nishikawa; Y Imai
Journal:  Heart Vessels       Date:  1993       Impact factor: 2.037

7.  'Split tolerance' induction by intrathymic injection of acetylcholine receptor in a rat model of autoimmune myasthenia gravis; implications for the design of specific immunotherapies.

Authors:  I Ohtsuru; H Matsuo; T Fukudome; A Suenaga; M Tsujihata; S Nagataki
Journal:  Clin Exp Immunol       Date:  1995-12       Impact factor: 4.330

8.  Pretransplant intrathymic inoculation of donor antigen combined with FK506 treatment: prolongation of survival of cardiac, but not renal, allografts in rats.

Authors:  K Motoyama; T Kamei; T Arima; M Ueki; T Hirano; Y Nakafusa; M Tanaka
Journal:  World J Surg       Date:  1995 Mar-Apr       Impact factor: 3.352

9.  Intrathymic injection of donor alloantigens induces donor-specific vascularized allograft tolerance without immunosuppression.

Authors:  J A Goss; Y Nakafusa; M W Flye
Journal:  Ann Surg       Date:  1992-10       Impact factor: 12.969

10.  Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide.

Authors:  S J Khoury; M H Sayegh; W W Hancock; L Gallon; C B Carpenter; H L Weiner
Journal:  J Exp Med       Date:  1993-08-01       Impact factor: 14.307
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