Literature DB >> 16723600

Effect of porins and plasmid-mediated AmpC beta-lactamases on the efficacy of beta-lactams in rat pneumonia caused by Klebsiella pneumoniae.

Emma Padilla1, Diana Alonso, Antonio Doménech-Sánchez, Cristina Gomez, José Luis Pérez, Sebastián Albertí, Nuria Borrell.   

Abstract

The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC beta-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No differences between these activities were seen with K. pneumoniae 12. Only meropenem showed an activity slightly better than that of imipenem with K. pneumoniae 12dp.

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Year:  2006        PMID： 16723600      PMCID： PMC1479113          DOI： 10.1128/AAC.01513-05

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

Review 1.  AmpC beta-lactamases: what do we need to know for the future?

Authors:  Nancy D Hanson
Journal:  J Antimicrob Chemother       Date:  2003-05-29       Impact factor: 5.790

2.  Efficacies of cefepime, ceftazidime, and imipenem alone or in combination with amikacin in rats with experimental pneumonia due to ceftazidime-susceptible or -resistant Enterobacter cloacae strains.

Authors:  O Mimoz; A Jacolot; S Leotard; N Hidri; K Samii; P Nordmann; O Petitjean
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

3.  Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 beta-Lactamase.

Authors:  Cristina Pichardo; José Manuel Rodríguez-Martínez; María E Pachón-Ibañez; Carmen Conejo; José Ibáñez-Martínez; Luis Martínez-Martínez; Jerónimo Pachón; Alvaro Pascual
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

4.  Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.

Authors:  L Martínez-Martínez; A Pascual; S Hernández-Allés; D Alvarez-Díaz; A I Suárez; J Tran; V J Benedí; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

5.  Porin expression in clinical isolates of Klebsiella pneumoniae.

Authors:  Santiago Hernández-Allés; Sebastián Albertí; Dolores Álvarez; Antonio Doménech-Sánchez; Luis Martínez-Martínez; José Gil; Juan M Tomás; Vicente J Benedí
Journal:  Microbiology       Date:  1999-03       Impact factor: 2.777

6.  Antimicrobial resistance amongst Klebsiella spp. collected from intensive care units in Southern and Western Europe in 1997-1998.

Authors:  G S Babini; D M Livermore
Journal:  J Antimicrob Chemother       Date:  2000-02       Impact factor: 5.790

7.  Efficacies of imipenem, meropenem, cefepime, and ceftazidime in rats with experimental pneumonia due to a carbapenem-hydrolyzing beta-lactamase-producing strain of Enterobacter cloacae.

Authors:  O Mimoz; S Leotard; A Jacolot; C Padoin; K Louchahi; O Petitjean; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2000-04       Impact factor: 5.191

8.  Activity of cefepime and carbapenems in experimental pneumonia caused by porin-deficient Klebsiella pneumoniae producing FOX-5 beta-lactamase.

Authors:  C Pichardo; M del Carmen Conejo; M Bernabéu-Wittel; A Pascual; M E Jiménez-Mejías; M de Cueto; M E Pachón-Ibáñez; I García; J Pachón; L Martínez-Martínez
Journal:  Clin Microbiol Infect       Date:  2005-01       Impact factor: 8.067

9.  Emergence of Klebsiella pneumoniae isolates producing inducible DHA-1 beta-lactamase in a university hospital in Taiwan.

Authors:  Jing-Jou Yan; Wen-Chien Ko; Yun-Chih Jung; Chin-Luan Chuang; Jiunn-Jong Wu
Journal:  J Clin Microbiol       Date:  2002-09       Impact factor: 5.948

10.  Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States.

Authors:  M Alvarez; J H Tran; N Chow; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191
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  4 in total

1.  Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence.

Authors:  Yu-Kuo Tsai; Chang-Phone Fung; Jung-Chung Lin; Jiun-Han Chen; Feng-Yee Chang; Te-Li Chen; L Kristopher Siu
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

2.  Predictability of Phenotype in Relation to Common β-Lactam Resistance Mechanisms in Escherichia coli and Klebsiella pneumoniae.

Authors:  Alex Agyekum; Alicia Fajardo-Lubián; Xiaoman Ai; Andrew N Ginn; Zhiyong Zong; Xuejun Guo; John Turnidge; Sally R Partridge; Jonathan R Iredell
Journal:  J Clin Microbiol       Date:  2016-02-24       Impact factor: 5.948

3.  Impact of derepressed AmpC beta-lactamase ACT-9 on the clinical efficacy of ertapenem.

Authors:  Yi-Tzu Lee; Te-Li Chen; Leung-Kei Siu; Chien-Pei Chen; Chang-Phone Fung
Journal:  Antimicrob Agents Chemother       Date:  2011-06-20       Impact factor: 5.191

Review 4.  AmpC beta-lactamases.

Authors:  George A Jacoby
Journal:  Clin Microbiol Rev       Date:  2009-01       Impact factor: 26.132
  4 in total

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