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Literature DB >> 16723594

Idebenone acts against growth of Helicobacter pylori by inhibiting its respiration.

Sakiko Inatsu¹, Ayumi Ohsaki, Kumiko Nagata.

Abstract

Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q(1) at low concentrations of 0.8 to 3.2 mug/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.

Entities: Chemical Species

Mesh：

Substances：

Year: 2006 PMID： 16723594 PMCID： PMC1479114 DOI： 10.1128/AAC.01118-05

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

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5 in total