Literature DB >> 16723593

Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

Colin S Osborne1, Ingrid Leitner, Bettina Hofbauer, Ceri A Fielding, Bertrand Favre, Neil S Ryder.   

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

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Year:  2006        PMID： 16723593      PMCID： PMC1479141          DOI： 10.1128/AAC.01600-05

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance.

Authors:  Márcia Eliana da Silva Ferreira; José Luiz Capellaro; Everaldo dos Reis Marques; Iran Malavazi; David Perlin; Steven Park; James B Anderson; Arnaldo L Colombo; Beth A Arthington-Skaggs; Maria Helena S Goldman; Gustavo H Goldman
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

2.  Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine.

Authors:  B Favre; N S Ryder
Journal:  Arch Biochem Biophys       Date:  1997-04-15       Impact factor: 4.013

3.  In vitro susceptibility to itraconazole, clotrimazole, ketoconazole and terbinafine of 100 isolates of Trichophyton rubrum.

Authors:  B Fernández-Torres; H Vázquez-Veiga; X Llovo; M Pereiro; J Guarro
Journal:  Chemotherapy       Date:  2000 Nov-Dec       Impact factor: 2.544

4.  Comparison of in vitro activities of voriconazole and five established antifungal agents against different species of dermatophytes using a broth macrodilution method.

Authors:  S Perea; A W Fothergill; D A Sutton; M G Rinaldi
Journal:  J Clin Microbiol       Date:  2001-01       Impact factor: 5.948

5.  Antifungal susceptibilities and genetic relatedness of serial Trichophyton rubrum isolates from patients with onychomycosis of the toenail.

Authors:  M C Bradley; S Leidich; N Isham; B E Elewski; M A Ghannoum
Journal:  Mycoses       Date:  1999       Impact factor: 4.377

Review 6.  Resistance of human fungal pathogens to antifungal drugs.

Authors:  Dominique Sanglard
Journal:  Curr Opin Microbiol       Date:  2002-08       Impact factor: 7.934

7.  Evaluation of in vitro resistance in patients with onychomycosis who fail antifungal therapy.

Authors:  Aditya K Gupta; Yatika Kohli
Journal:  Dermatology       Date:  2003       Impact factor: 5.366

8.  Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents.

Authors:  B Favre; N S Ryder
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

9.  Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae.

Authors:  Regina Leber; Sandra Fuchsbichler; Vlasta Klobucníková; Natascha Schweighofer; Eva Pitters; Kathrin Wohlfarter; Mojca Lederer; Karina Landl; Christoph Ruckenstuhl; Ivan Hapala; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

10.  In vitro susceptibility of Microsporum canis and other dermatophyte isolates from veterinary infections during therapy with terbinafine or griseofulvin.

Authors:  B Hofbauer; I Leitner; N S Ryder
Journal:  Med Mycol       Date:  2002-04       Impact factor: 4.076
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  25 in total

Review 1.  Strain differentiation of dermatophytes.

Authors:  Susan M Abdel-Rahman
Journal:  Mycopathologia       Date:  2008-05-14       Impact factor: 2.574

2.  The Growing Problem of Antifungal Resistance in Onychomycosis and Other Superficial Mycoses.

Authors:  Aditya K Gupta; Helen J Renaud; Emma M Quinlan; Neil H Shear; Vincent Piguet
Journal:  Am J Clin Dermatol       Date:  2020-12-22       Impact factor: 7.403

3.  Antimicrobial activity of Paenibacillus kribbensis POC 115 against the dermatophyte Trichophyton rubrum.

Authors:  Simone Raposo Cotta; Fabio Faria da Mota; Gleiser Tupinambá; Kelly Ishida; Sonia Rozental; Davi Oliveira E Silva; Antônio Jorge Ribeiro da Silva; Humberto Ribeiro Bizzo; Daniela Sales Alviano; Celuta Sales Alviano; Lucy Seldin
Journal:  World J Microbiol Biotechnol       Date:  2011-10-01       Impact factor: 3.312

4.  Silicon phthalocyanine 4 phototoxicity in Trichophyton rubrum.

Authors:  Minh Lam; Matthew L Dimaano; Patricia Oyetakin-White; Mauricio A Retuerto; Jyotsna Chandra; Pranab K Mukherjee; Mahmoud A Ghannoum; Kevin D Cooper; Elma D Baron
Journal:  Antimicrob Agents Chemother       Date:  2014-03-10       Impact factor: 5.191

5.  Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine Resistance.

Authors:  Shivaprakash M Rudramurthy; Shamanth A Shankarnarayan; Sunil Dogra; Dipika Shaw; Khurram Mushtaq; Raees A Paul; Tarun Narang; Arunaloke Chakrabarti
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

6.  Antifungal drug susceptibility profile of clinically important dermatophytes and determination of point mutations in terbinafine-resistant isolates.

Authors:  Zahra Salehi; Masoomeh Shams-Ghahfarokhi; Mehdi Razzaghi-Abyaneh
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2018-07-07       Impact factor: 3.267

7.  Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene.

Authors:  Tsuyoshi Yamada; Mari Maeda; Mohamed Mahdi Alshahni; Reiko Tanaka; Takashi Yaguchi; Olympia Bontems; Karine Salamin; Marina Fratti; Michel Monod
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

8.  Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection.

Authors:  Ditte M L Saunte; Rasmus K Hare; Karin M Jørgensen; René Jørgensen; Mette Deleuran; Claus O Zachariae; Simon F Thomsen; Lars Bjørnskov-Halkier; Kristian Kofoed; Maiken C Arendrup
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

9.  Characterization of squalene epoxidase of Saccharomyces cerevisiae by applying terbinafine-sensitive variants.

Authors:  Christoph Ruckenstuhl; Silvia Lang; Andrea Poschenel; Armin Eidenberger; Pravas Kumar Baral; Peter Kohút; Ivan Hapala; Karl Gruber; Friederike Turnowsky
Journal:  Antimicrob Agents Chemother       Date:  2006-10-16       Impact factor: 5.191

Review 10.  The unprecedented epidemic-like scenario of dermatophytosis in India: III. Antifungal resistance and treatment options.

Authors:  Shyam B Verma; Saumya Panda; Pietro Nenoff; Archana Singal; Shivprakash M Rudramurthy; Silke Uhrlass; Anupam Das; Kavita Bisherwal; Dipika Shaw; Resham Vasani
Journal:  Indian J Dermatol Venereol Leprol       Date:  2021 [SEASON]       Impact factor: 2.545
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