Literature DB >> 1672286

Alphoid DNA polymorphisms for chromosome 21 can be distinguished from those of chromosome 13 using probes homologous to both.

E W Jabs1, A C Warren, E W Taylor, C R Colyer, D A Meyers, S E Antonarakis.   

Abstract

Although alphoid DNA sequences shared among acrocentric chromosomes have been identified, no human chromosome 21-specific sequence has been isolated from the centromeric region. To identify alphoid DNA restriction fragment length polymorphisms (RFLPs) specific for chromosome 21, we hybridized human genomic DNA with alphoid DNA probes [L1.26; aRI(680),21-208] shared by chromosomes 13 and 21. We detected RFLPs with restriction enzymes ECoRI, HaeIII, MboI,StuI, and TaqI. The segregation of these RFLPs was analyzed in the 40 CEPH families. Linkage analysis between these RFLPs and loci previously mapped to either chromosome 13 or 21 revealed RFLPs that appear to be specific to chromosome 21. These polymorphisms may be useful as genetic markers of the centromeric region of chromosome 21. Different alphoid loci within the centromeric region of chromosome 13 were identified.

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Year:  1991        PMID： 1672286     DOI： 10.1016/0888-7543(91)90231-3

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  12 in total

1.  Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome.

Authors:  M B Peterson; M Frantzen; S E Antonarakis; A C Warren; C Van Broeckhoven; A Chakravarti; T K Cox; C Lund; B Olsen; H Poulsen
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

2.  Nondisjunction of chromosome 21: comparisons of cytogenetic and molecular studies of the meiotic stage and parent of origin.

Authors:  B J Lorber; M Grantham; J Peters; H F Willard; T J Hassold
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025

3.  DNA polymorphism analysis in families with recurrence of free trisomy 21.

Authors:  C G Pangalos; C C Talbot; J G Lewis; P A Adelsberger; M B Petersen; J L Serre; M O Rethoré; M C de Blois; P Parent; A A Schinzel
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

Review 4.  A survey of the genomic distribution of alpha satellite DNA on all the human chromosomes, and derivation of a new consensus sequence.

Authors:  K H Choo; B Vissel; A Nagy; E Earle; P Kalitsis
Journal:  Nucleic Acids Res       Date:  1991-03-25       Impact factor: 16.971

5.  Trisomy 21: association between reduced recombination and nondisjunction.

Authors:  S L Sherman; N Takaesu; S B Freeman; M Grantham; C Phillips; R D Blackston; P A Jacobs; A E Cockwell; V Freeman; I Uchida
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

6.  Organization and evolution of an alpha satellite DNA subset shared by human chromosomes 13 and 21.

Authors:  G M Greig; P E Warburton; H F Willard
Journal:  J Mol Evol       Date:  1993-11       Impact factor: 2.395

7.  A polymorphic alpha satellite sequence specific for human chromosome 13 detected by oligonucleotide primed in situ labelling (PRINS).

Authors:  F Pellestor; A Girardet; B Andréo; J P Charlieu
Journal:  Hum Genet       Date:  1994-10       Impact factor: 4.132

8.  Nondisjunction of human acrocentric chromosomes: studies of 432 trisomic fetuses and liveborns.

Authors:  M V Zaragoza; P A Jacobs; R S James; P Rogan; S Sherman; T Hassold
Journal:  Hum Genet       Date:  1994-10       Impact factor: 4.132

9.  A rapid and simple method to isolate and characterize highly polymorphic markers from the centromeric regions of the human chromosomes.

Authors:  A M Laurent; B Marçais; M Muleris; G Roizès
Journal:  Nucleic Acids Res       Date:  1994-01-25       Impact factor: 16.971

10.  Meiotic crossing-over in nondisjoined chromosomes of children with trisomy 21 and a congenital heart defect.

Authors:  C M Howard; G E Davies; M J Farrer; L M Cullen; M M Coleman; R Williamson; R K Wyse; R Palmer; A M Kessling
Journal:  Am J Hum Genet       Date:  1993-08       Impact factor: 11.025
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