Literature DB >> 16722826

Reflections on the 'discovery' of the antimalarial qinghao.

Elisabeth Hsu1.   

Abstract

Artemisinin, qinghaosu, was extracted from the traditional Chinese medical drug qinghao (the blue-green herb) in the early 1970s. Its 'discovery' can thus be hailed as an achievement of research groups who were paradoxically successful, working as they were at the height of a political mass movement in communist China, known in the West as the Cultural Revolution (1966-1976), a period that was marked by chaos, cruelty and enormous suffering, particularly, but by no means only, among the intelligentsia. On the one hand, China's cultural heritage was seen as a hindrance to progress and Mao set out to destroy it, but on the other hand he praised it as a 'treasure house', full of gems that, if adjusted to the demands of contemporary society, could be used 'for serving the people' (wei renmin fuwu). The success of the 'task of combating malaria' (kang nüe ren wu), sometimes known as 'task number five hundred and twenty-three', depended crucially on modern scientists who took seriously knowledge that was recorded in a traditional Chinese medical text, Emergency Prescriptions Kept up one's Sleeve by the famous physician Ge Hong (284-363).

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Year:  2006        PMID: 16722826      PMCID: PMC1885105          DOI: 10.1111/j.1365-2125.2006.02673.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  2 in total

1.  Diverse biologies and experiential continuities: did the ancient Chinese know that qinghao had anti-malarial properties?

Authors:  Elisabeth Hsu
Journal:  Can Bull Med Hist       Date:  2009

Review 2.  Qinghaosu.

Authors:  T T Hien; N J White
Journal:  Lancet       Date:  1993-03-06       Impact factor: 79.321

  2 in total
  23 in total

1.  From branch to bedside: Youyou Tu is awarded the 2011 Lasker~DeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria.

Authors:  Ushma S Neill
Journal:  J Clin Invest       Date:  2011-10       Impact factor: 14.808

Review 2.  Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.

Authors:  Chris J Paddon; Jay D Keasling
Journal:  Nat Rev Microbiol       Date:  2014-04-01       Impact factor: 60.633

3.  pH-responsive artemisinin dimer in lipid nanoparticles are effective against human breast cancer in a xenograft model.

Authors:  Yitong J Zhang; Xi Zhan; Liguo Wang; Rodney J Y Ho; Tomikazu Sasaki
Journal:  J Pharm Sci       Date:  2015-03-09       Impact factor: 3.534

4.  Newborn care and knowledge translation - perceptions among primary healthcare staff in northern Vietnam.

Authors:  Leif Eriksson; Nguyen Thu Nga; Dinh P Hoa; Lars-Åke Persson; Uwe Ewald; Lars Wallin
Journal:  Implement Sci       Date:  2011-03-29       Impact factor: 7.327

Review 5.  Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production.

Authors:  Neha Pandey; Shashi Pandey-Rai
Journal:  Protoplasma       Date:  2015-03-27       Impact factor: 3.356

Review 6.  Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.

Authors:  Rocky Graziose; Mary Ann Lila; Ilya Raskin
Journal:  Curr Drug Discov Technol       Date:  2010-03

Review 7.  Hemozoin and antimalarial drug discovery.

Authors:  Kim Y Fong; David W Wright
Journal:  Future Med Chem       Date:  2013-08       Impact factor: 3.808

Review 8.  Discovery, mechanisms of action and combination therapy of artemisinin.

Authors:  Liwang Cui; Xin-zhuan Su
Journal:  Expert Rev Anti Infect Ther       Date:  2009-10       Impact factor: 5.091

Review 9.  Compounds from Chinese herbal medicines as reversal agents for P-glycoprotein-mediated multidrug resistance in tumours.

Authors:  C Li; B-Q Sun; X-D Gai
Journal:  Clin Transl Oncol       Date:  2014-03-19       Impact factor: 3.405

10.  Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond.

Authors:  Priya Nair; Maneesha Mall; Pooja Sharma; Feroz Khan; Dinesh A Nagegowda; Prasant K Rout; Madan M Gupta; Alok Pandey; Ajit K Shasany; Anil K Gupta; Ashutosh K Shukla
Journal:  Plant Mol Biol       Date:  2019-05-15       Impact factor: 4.076

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