| Literature DB >> 16722655 |
Haitao Li1, Kenna L Anderes, Eugenia A Kraynov, David R Luthin, Quyen-Quyen Do, Yufeng Hong, Eileen Tompkins, Eric T Sun, Ranjan Rajapakse, Ved P Pathak, Lance C Christie, Jun Feng, Haresh Vazir, Rosemary Castillo, Margaret L Gregory, Mary Castro, Karen Nared-Hood, Genevieve Paderes, Mark B Anderson.
Abstract
Gonadotropin releasing hormone (GnRH) plays an important role in the biology of reproduction. The use of GnRH receptor antagonists has been reported in the literature for the treatment of breast, ovarian, and prostate cancers. In this article, we report the synthesis, in vitro characterization, pharmacokinetics, and pharmacodynamics of an orally bioavailable, potent, small molecule GnRH receptor antagonist N-{4,6-dimethoxy-2-[(3-morpholin-4-ylpropyl)amino]pyrimidin-5-yl}-5-[3,3,6-trimthyl-2,3-dihydro-1H-inden-5-yl)oxy]-2-furamide (compound 1).Entities:
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Year: 2006 PMID： 16722655 DOI： 10.1021/jm060012g
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446