Literature DB >> 16722647

Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen.

Jeroen Kool1, Rawi Ramautar, Sebastiaan M van Liempd, Joran Beckman, Frans J J de Kanter, John H N Meerman, Tim Schenk, Hubertus Irth, Jan N M Commandeur, Nico P E Vermeulen.   

Abstract

Here we present a high-resolution screening (HRS) methodology for postcolumn on-line profiling of metabolites with affinity for the estrogen receptor alpha (ERalpha). Tamoxifen, which is metabolized into multiple metabolites, was used as the model compound. Most of the 14 metabolites detected exhibited affinity for the ERalpha. The HRS methodology shows great potential for metabolite bio-affinity profiling and application in drug discovery and development.

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Year:  2006        PMID： 16722647     DOI： 10.1021/jm0507936

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  7 in total

1.  Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography.

Authors:  Alexandre Maciuk; Ruin Moaddel; Jun Haginaka; Irving W Wainer
Journal:  J Pharm Biomed Anal       Date:  2007-11-26       Impact factor: 3.935

2.  Development of On-line Liquid Chromatography-Biochemical Detection for Soluble Epoxide Hydrolase Inhibitors in Mixtures.

Authors:  David Falck; Nils Helge Schebb; Setyo Prihatiningtyas; Jiawen Zhang; Ferry Heus; Christophe Morisseau; Jeroen Kool; Bruce D Hammock; Wilfried M A Niessen
Journal:  Chromatographia       Date:  2012-11-07       Impact factor: 2.044

3.  Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer.

Authors:  Jennifer Gjerde; Jürgen Geisler; Steinar Lundgren; Dagfinn Ekse; Jan Erik Varhaug; Gunnar Mellgren; Vidar M Steen; Ernst A Lien
Journal:  BMC Cancer       Date:  2010-06-21       Impact factor: 4.430

Review 4.  Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures.

Authors:  Jeroen Kool; Martin Giera; Hubertus Irth; Wilfried M A Niessen
Journal:  Anal Bioanal Chem       Date:  2010-11-24       Impact factor: 4.142

Review 5.  Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.

Authors:  Christiaan J Malherbe; Dalene De Beer; Elizabeth Joubert
Journal:  Int J Mol Sci       Date:  2012-03-07       Impact factor: 6.208

Review 6.  "Commandeuring" Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism.

Authors:  Barbara M A van Vugt-Lussenburg; Liliana Capinha; Jelle Reinen; Martijn Rooseboom; Michel Kranendonk; Rob C A Onderwater; Paul Jennings
Journal:  Chem Res Toxicol       Date:  2022-06-29       Impact factor: 3.973

7.  Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization.

Authors:  Jelle Reinen; Jeroen Kool; Nico P E Vermeulen
Journal:  Anal Bioanal Chem       Date:  2008-01-31       Impact factor: 4.142
  7 in total

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