Literature DB >> 16721049

Double bolt regulation of Rad51 by p53: a role for transcriptional repression.

Iciar Lazaro-Trueba1, Carmen Arias, Augusto Silva.   

Abstract

The regulation of homologous recombination (HR) by p53 has been currently associated with its nontransactivating function; now the transcriptional repression of the Rad51 gene by p53 has been elucidated. This extra control by p53 involves the transcriptional downregulation of Rad51 protein, which in turn accounts for the reduction of functional Rad51 foci. Down regulation of Rad51 protein might be relevant, considering that Rad51 is a rate-limiting factor in HR. Moreover, impaired Rad51-repression by p53 mutant proteins may contribute to malignant transformation.

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Year:  2006        PMID： 16721049     DOI： 10.4161/cc.5.10.2764

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  11 in total

1.  Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells.

Authors:  Marc J Rigatti; Rajeev Verma; Glenn S Belinsky; Daniel W Rosenberg; Charles Giardina
Journal:  Mol Carcinog       Date:  2011-05-06       Impact factor: 4.784

2.  Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill.

Authors:  Xiaolei Xie; Guangan He; Zahid H Siddik
Journal:  Mol Pharmacol       Date:  2020-02-16       Impact factor: 4.436

3.  Replicational stress selects for p53 mutation.

Authors:  Andriy Marusyk; James DeGregori
Journal:  Cell Cycle       Date:  2007-07-10       Impact factor: 4.534

4.  A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

Authors:  M Kracikova; G Akiri; A George; R Sachidanandam; S A Aaronson
Journal:  Cell Death Differ       Date:  2013-01-11       Impact factor: 15.828

5.  PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy.

Authors:  Michael Fraser; Helen Zhao; Kaisa R Luoto; Cecilia Lundin; Carla Coackley; Norman Chan; Anthony M Joshua; Tarek A Bismar; Andrew Evans; Thomas Helleday; Robert G Bristow
Journal:  Clin Cancer Res       Date:  2011-11-23       Impact factor: 12.531

Review 6.  One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor.

Authors:  Levin Böhlig; Karen Rother
Journal:  J Biomed Biotechnol       Date:  2011-03-08

7.  RDM1 plays an oncogenic role in human lung adenocarcinoma cells.

Authors:  Lu Tong; Jian Liu; Wangjun Yan; Wenjiao Cao; Shihui Shen; Kun Li; Lei Li; Guoping Niu
Journal:  Sci Rep       Date:  2018-08-01       Impact factor: 4.379

Review 8.  Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.

Authors:  David Schild; Claudia Wiese
Journal:  Nucleic Acids Res       Date:  2009-11-26       Impact factor: 16.971

9.  Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro.

Authors:  Or David Shahar; Ronen Gabizon; Oren Feine; Raphael Alhadeff; Assaf Ganoth; Liron Argaman; Elee Shimshoni; Assaf Friedler; Michal Goldberg
Journal:  PLoS One       Date:  2013-10-23       Impact factor: 3.240

10.  Metformin Radiosensitizes p53-Deficient Colorectal Cancer Cells through Induction of G2/M Arrest and Inhibition of DNA Repair Proteins.

Authors:  Youn Kyoung Jeong; Mi-Sook Kim; Ji Young Lee; Eun Ho Kim; Hunjoo Ha
Journal:  PLoS One       Date:  2015-11-23       Impact factor: 3.240
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