| Literature DB >> 16720920 |
Yasunori Hashiguchi1, Hiroshi Tsuda, Christina A Bandera, Sadako Nishimura, Takeshi Inoue, Naoki Kawamura, Ross S Berkowitz, Samuel C Mok.
Abstract
This study compared the DNA, RNA, and protein levels of osteopontin (OPN) in endometrioid endometrial cancer (EEC) and ovarian endometrioid cancer (OEC). In total, 63 cancer cases (EEC: 33, OEC: 30) were included. Of these, 47 (EEC: 26, OEC: 21) were examined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and 48 (EEC: 25, OEC: 23) were examined by quantitative PCR. OPN expression was detected in 15 (50.0%) of 30 EECs and in 14 (50.0%) of 28 OECs. There was no significant difference in the percentage of positive cytoplasmic OPN staining between the EECs and OECs (12.8 vs 10.4; p = 0.6811). The correlation between relative mRNA and protein expression levels was significant in both the EECs and OECs; however, the correlation between relative DNA and mRNA levels was not significant. There was no significant difference in OPN expression between the EECs and OECs.Entities:
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Year: 2006 PMID： 16720920 DOI： 10.1385/MO:23:2:205
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064