Literature DB >> 16720737

Positive effects of 17beta-estradiol on insulin sensitivity in aged ovariectomized female rats.

Ana Alonso1, Rebeca Fernández, María Moreno, Patricia Ordóñez, Héctor González-Pardo, Nélida M Conejo, Fernando Díaz, Celestino González.   

Abstract

Aging is associated with insulin resistance, which represents a common factor in age-related diseases. We aimed to determine the role of 17beta-estradiol on insulin sensitivity and memory during aging using ovariectomized rats (2-26 months of age) treated with physiological doses of 17beta-estradiol. Our results indicate a lack of effect of 17beta-estradiol replacement on spatial memory assessed in a water maze. Conversely, estradiol treatment improved insulin sensitivity in aging rats. These data imply that relatively low doses of 17beta-estradiol may have beneficial effects on glucose homeostasis due to the protective effects of estrogen. However, estradiol treatment used in the present study did not prevent memory impairment associated with aging.

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Year:  2006        PMID： 16720737     DOI： 10.1093/gerona/61.5.419

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  9 in total

Review 1.  Using the cerebrospinal fluid to understand ingestive behavior.

Authors:  Stephen C Woods; Aaron A May; Min Liu; Patrick Tso; Denovan P Begg
Journal:  Physiol Behav       Date:  2016-12-05

2.  Acute effects of 17 β-estradiol and genistein on insulin sensitivity and spatial memory in aged ovariectomized female rats.

Authors:  Ana Alonso; Héctor González-Pardo; Pablo Garrido; Nélida M Conejo; Plácido Llaneza; Fernando Díaz; Carmen González Del Rey; Celestino González
Journal:  Age (Dordr)       Date:  2010-05-14

3.  Impaired PI3 K Akt expression in liver and skeletal muscle of ovariectomized rats.

Authors:  Yan Wang; Baoxin Li; Wei Zhang; Yan Liu; Peng Xue; Jianxia Ma; Yukun Li
Journal:  Endocrine       Date:  2013-02-02       Impact factor: 3.633

4.  Estrogen and insulin transport through the blood-brain barrier.

Authors:  Aaron A May; Nicholas D Bedel; Ling Shen; Stephen C Woods; Min Liu
Journal:  Physiol Behav       Date:  2016-05-13

5.  The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries.

Authors:  Kathleen M Eyster; Connie J Mark; Richard Gayle; Douglas S Martin
Journal:  Vascul Pharmacol       Date:  2007-07-03       Impact factor: 5.773

6.  Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging.

Authors:  M Moreno; P Ordoñez; A Alonso; F Díaz; J Tolivia; C González
Journal:  Age (Dordr)       Date:  2009-05-22

7.  In vivo stimulation of oestrogen receptor α increases insulin-stimulated skeletal muscle glucose uptake.

Authors:  Brittany K Gorres; Gregory L Bomhoff; Jill K Morris; Paige C Geiger
Journal:  J Physiol       Date:  2011-02-21       Impact factor: 5.182

8.  Chronic treatment with the nitric oxide synthase inhibitor, L-NAME, attenuates estradiol-mediated improvement of learning and memory in ovariectomized rats.

Authors:  Hamid Azizi-Malekabadi; Mahmoud Hosseini; Fatima Saffarzadeh; Reza Karami; Fatimeh Khodabandehloo
Journal:  Clinics (Sao Paulo)       Date:  2011       Impact factor: 2.365

Review 9.  Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.

Authors:  Paola De Marco; Francesca Cirillo; Adele Vivacqua; Roberta Malaguarnera; Antonino Belfiore; Marcello Maggiolini
Journal:  Front Endocrinol (Lausanne)       Date:  2015-03-06       Impact factor: 5.555
  9 in total

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