UNLABELLED: Recognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non-specific white and grey matter lesions, vascular anomalies, in particular dolicho-ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age. CONCLUSION: MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.
UNLABELLED: Recognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non-specific white and grey matter lesions, vascular anomalies, in particular dolicho-ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age. CONCLUSION: MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.
Authors: Hunter R Underhill; Katie Golden-Grant; Lauren T Garrett; Stefanie Uhrich; Brandon A Zielinski; C Ronald Scott Journal: J Magn Reson Imaging Date: 2015-05-27 Impact factor: 4.813
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