Literature DB >> 1672040

Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products.

D H Yan1, L S Chang, M C Hung.   

Abstract

The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsible for the repression of HER-2/c-erbB-2 at the RNA level.

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Year:  1991        PMID： 1672040

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  16 in total

Review 1.  Transcriptional regulation of type I receptor tyrosine kinases in the mammary gland.

Authors:  N P Bates; H C Hurst
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-04       Impact factor: 2.673

2.  Negative autoregulation of the neu gene is mediated by a novel enhancer.

Authors:  X Y Zhao; M C Hung
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

3.  p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing.

Authors:  M B Flinterman; J S Mymryk; P Klanrit; A F Yousef; S W Lowe; C Caldas; J Gäken; F Farzaneh; M Tavassoli
Journal:  Oncogene       Date:  2007-05-07       Impact factor: 9.867

4.  Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.

Authors:  H Yamaguchi; C-T Chen; C-K Chou; A Pal; W Bornmann; G N Hortobagyi; M-C Hung
Journal:  Oncogene       Date:  2010-08-02       Impact factor: 9.867

5.  Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene.

Authors:  Paul M Loewenstein; Maurice Green
Journal:  Genes Cancer       Date:  2011-07

6.  Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.

Authors:  W P Lee; Y Liao; D Robinson; H J Kung; E T Liu; M C Hung
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

7.  Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells.

Authors:  Vera L Tarakanova; William S M Wold
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

8.  Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.

Authors:  G F Verheijden; W H Moolenaar; H L Ploegh
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

9.  Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.

Authors:  Chia-Jui Yen; Julie G Izzo; Dung-Fang Lee; Sushovan Guha; Yongkun Wei; Tsung-Teh Wu; Chun-Te Chen; Hsu-Ping Kuo; Jung-Mao Hsu; Hui-Lung Sun; Chao-Kai Chou; Navtej S Buttar; Kenneth K Wang; Peng Huang; Jaffer Ajani; Mien-Chie Hung
Journal:  Cancer Res       Date:  2008-04-15       Impact factor: 12.701

10.  Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin.

Authors:  Poramaporn Klanrit; Marcella B Flinterman; Edward W Odell; Gerry Melino; Richard Killick; James S Norris; Mahvash Tavassoli
Journal:  Cell Cycle       Date:  2007-11-16       Impact factor: 4.534
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