Literature DB >> 16720343

Epstein-Barr virus (EBV) and its associated human cancers--genetics, epigenetics, pathobiology and novel therapeutics.

Qian Tao1, Lawrence S Young, Ciaran B J Woodman, Paul G Murray.   

Abstract

Epstein-Barr virus (EBV) is a B-lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumors the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers, and illustrates how a deeper insight into viral latent gene expression, regulation and functions in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies targeting EBV in tumors are discussed.

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Year:  2006        PMID： 16720343     DOI： 10.2741/2000

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  53 in total

1.  Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents.

Authors:  Sajal K Ghosh; Susan P Perrine; Robert M Williams; Douglas V Faller
Journal:  Blood       Date:  2011-12-07       Impact factor: 22.113

Review 2.  The role of viral and bacterial pathogens in gastrointestinal cancer.

Authors:  Michael Selgrad; Peter Malfertheiner; Lucia Fini; Ajay Goel; C Richard Boland; Luigi Ricciardiello
Journal:  J Cell Physiol       Date:  2008-08       Impact factor: 6.384

Review 3.  Spectrum of Epstein-Barr virus-related diseases: a pictorial review.

Authors:  Eriko Maeda; Masaaki Akahane; Shigeru Kiryu; Nobuyuki Kato; Takeharu Yoshikawa; Naoto Hayashi; Shigeki Aoki; Manabu Minami; Hiroshi Uozaki; Masashi Fukayama; Kuni Ohtomo
Journal:  Jpn J Radiol       Date:  2009-02-08       Impact factor: 2.374

4.  The p38 signaling pathway upregulates expression of the Epstein-Barr virus LMP1 oncogene.

Authors:  Pegah Johansson; Ann Jansson; Ulla Rüetschi; Lars Rymo
Journal:  J Virol       Date:  2010-01-06       Impact factor: 5.103

5.  Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma.

Authors:  Sarah Leonard; Wenbin Wei; Jennifer Anderton; Martina Vockerodt; Martin Rowe; Paul G Murray; Ciaran B Woodman
Journal:  J Virol       Date:  2011-07-13       Impact factor: 5.103

6.  Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells.

Authors:  Dominique L Ouellet; Patrick Provost
Journal:  Methods Mol Biol       Date:  2010

7.  Transcription factor RBPJ/CSL: a genome-wide look at transcriptional regulation.

Authors:  Lucio Miele
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-24       Impact factor: 11.205

Review 8.  Viruses associated with human cancer.

Authors:  Margaret E McLaughlin-Drubin; Karl Munger
Journal:  Biochim Biophys Acta       Date:  2007-12-23

9.  A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness.

Authors:  Andriy V Kubarenko; Satish Ranjan; Anna Rautanen; Tara C Mills; Sunny Wong; Fredrik Vannberg; Michael Neumaier; Isabelle Bekeredjian-Ding; Adrian V S Hill; Parviz Ahmad-Nejad; Alexander N R Weber
Journal:  J Biol Chem       Date:  2010-09-14       Impact factor: 5.157

10.  Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technology.

Authors:  Ai-Di Gu; Li-Xia Lu; Yan-Bo Xie; Li-Zhen Chen; Qi-Sheng Feng; Tiebang Kang; Wei-Hua Jia; Yi-Xin Zeng
Journal:  J Transl Med       Date:  2009-08-23       Impact factor: 5.531
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