Literature DB >> 16719804

A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

Paul M O'Neill1, Stephen A Ward, Neil G Berry, J Prince Jeyadevan, Giancarlo A Biagini, Egbaleh Asadollaly, B Kevin Park, Patrick G Bray.   

Abstract

A broad overview is presented describing the current knowledge and the ongoing research concerning the 4-aminoquinolines (4AQ) as chemotherapeutic antimalarial agents. Included are discussions of mechanism of action, structure activity relationships (SAR), chemistry, metabolism and toxicity and parasite resistance mechanisms. In discussions of SAR, particular emphasis has been given to activity versus chloroquine resistant strains of Plasmodium falciparum. Promising new lead compounds undergoing development are described and an overview of physicochemical properties of chloroquine and amodiaquine analogues is also included.

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Year:  2006        PMID： 16719804     DOI： 10.2174/156802606776743147

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  29 in total

1.  Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.

Authors:  Don Antoine Lanfranchi; Elena Cesar-Rodo; Benoît Bertrand; Hsin-Hung Huang; Latasha Day; Laure Johann; Mourad Elhabiri; Katja Becker; David L Williams; Elisabeth Davioud-Charvet
Journal:  Org Biomol Chem       Date:  2012-07-10       Impact factor: 3.876

Review 2.  Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches.

Authors:  Pedro N Batalha; Luana S M Forezi; Carolina G S Lima; Fernanda P Pauli; Fernanda C S Boechat; Maria Cecília B V de Souza; Anna C Cunha; Vitor F Ferreira; Fernando de C da Silva
Journal:  Bioorg Chem       Date:  2020-11-19       Impact factor: 5.275

Review 3.  Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.

Authors:  Robert L Summers; Megan N Nash; Rowena E Martin
Journal:  Cell Mol Life Sci       Date:  2012-06       Impact factor: 9.261

4.  Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands.

Authors:  Timothy J Hubin; Prince N-A Amoyaw; Kimberly D Roewe; Natalie C Simpson; Randall D Maples; TaRynn N Carder Freeman; Amy N Cain; Justin G Le; Stephen J Archibald; Shabana I Khan; Babu L Tekwani; M O Faruk Khan
Journal:  Bioorg Med Chem       Date:  2014-05-11       Impact factor: 3.641

5.  Ivermectin Impairs the Development of Sexual and Asexual Stages of Plasmodium falciparum In Vitro.

Authors:  Lais Pessanha de Carvalho; Thaisa Lucas Sandri; Edésio José Tenório de Melo; Rolf Fendel; Peter G Kremsner; Benjamin Mordmüller; Jana Held
Journal:  Antimicrob Agents Chemother       Date:  2019-07-25       Impact factor: 5.191

6.  Synthesis and evaluation of 7-substituted 4-aminoquinoline analogues for antimalarial activity.

Authors:  Jong Yeon Hwang; Takashi Kawasuji; David J Lowes; Julie A Clark; Michele C Connelly; Fangyi Zhu; W Armand Guiguemde; Martina S Sigal; Emily B Wilson; Joseph L Derisi; R Kiplin Guy
Journal:  J Med Chem       Date:  2011-09-26       Impact factor: 7.446

Review 7.  Plasmodium drug targets outside the genetic control of the parasite.

Authors:  David J Sullivan
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

8.  Sontochin as a guide to the development of drugs against chloroquine-resistant malaria.

Authors:  Sovitj Pou; Rolf W Winter; Aaron Nilsen; Jane Xu Kelly; Yuexin Li; J Stone Doggett; Erin W Riscoe; Keith W Wegmann; David J Hinrichs; Michael K Riscoe
Journal:  Antimicrob Agents Chemother       Date:  2012-04-16       Impact factor: 5.191

9.  Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.

Authors:  Fausta Omodeo-Salè; Lucia Cortelezzi; Nicoletta Basilico; Manolo Casagrande; Anna Sparatore; Donatella Taramelli
Journal:  Antimicrob Agents Chemother       Date:  2009-08-03       Impact factor: 5.191

10.  Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment.

Authors:  Katie R Hughes; Giancarlo A Biagini; Alister G Craig
Journal:  Mol Biochem Parasitol       Date:  2009-10-01       Impact factor: 1.759
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