Literature DB >> 16718482

The signal attenuation rat model of obsessive-compulsive disorder: a review.

Daphna Joel1.   

Abstract

During the last 30 years, there have been many attempts to develop animal models of obsessive-compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present paper reviews a recently developed rat model of OCD, namely, signal attenuation. Results of pharmacological and lesion studies are presented and evaluated with respect to the pharmacology and pathophysiology of OCD. It is argued that signal attenuation is a rat model of OCD with construct (derived from similarity in the underlying mechanisms), predictive (derived from similarity in response to treatment), and face (derived from phenomenological similarity between "compulsive" behavior in the model and compulsions in OCD patients) validity.

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Year:  2006        PMID： 16718482     DOI： 10.1007/s00213-006-0387-2

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  140 in total

1.  Changes in functional connectivity in orbitofrontal cortex and basolateral amygdala during learning and reversal training.

Authors:  G Schoenbaum; A A Chiba; M Gallagher
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

2.  Multicenter double-blind comparison of sertraline and desipramine for concurrent obsessive-compulsive and major depressive disorders.

Authors:  R Hoehn-Saric; P Ninan; D W Black; S Stahl; J H Greist; B Lydiard; S McElroy; J Zajecka; D Chapman; C Clary; W Harrison
Journal:  Arch Gen Psychiatry       Date:  2000-01

Review 3.  Functional MRI and the study of OCD: from symptom provocation to cognitive-behavioral probes of cortico-striatal systems and the amygdala.

Authors:  H C Breiter; S L Rauch
Journal:  Neuroimage       Date:  1996-12       Impact factor: 6.556

4.  The acquisition of responding with conditioned reinforcement: effects of pipradrol, methylphenidate, d-amphetamine, and nomifensine.

Authors:  T W Robbins
Journal:  Psychopharmacology (Berl)       Date:  1978-06-15       Impact factor: 4.530

5.  Differential response of cortical-limbic neuropotentiated compulsive mice to dopamine D1 and D2 receptor antagonists.

Authors:  K M Campbell; M J McGrath; F H Burton
Journal:  Eur J Pharmacol       Date:  1999-04-29       Impact factor: 4.432

6.  Anxiety in a transgenic mouse model of cortical-limbic neuro-potentiated compulsive behavior.

Authors:  M J McGrath; K M Campbell; M B Veldman; F H Burton
Journal:  Behav Pharmacol       Date:  1999-09       Impact factor: 2.293

7.  Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.

Authors:  A Woods; C Smith; M Szewczak; R W Dunn; M Cornfeldt; R Corbett
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography.

Authors:  S L Rauch; M A Jenike; N M Alpert; L Baer; H C Breiter; C R Savage; A J Fischman
Journal:  Arch Gen Psychiatry       Date:  1994-01

9.  'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam.

Authors:  D Joel; E Ben-Amir; J Doljansky; S Flaisher
Journal:  Behav Pharmacol       Date:  2004-05       Impact factor: 2.293

10.  Spontaneous alternation behavior: an animal model for obsessive-compulsive disorder?

Authors:  E Yadin; E Friedman; W H Bridger
Journal:  Pharmacol Biochem Behav       Date:  1991-10       Impact factor: 3.533
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  18 in total

1.  Separate mechanisms for development and performance of compulsive checking in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).

Authors:  Mark C Tucci; Anna Dvorkin-Gheva; Renee Sharma; Leena Taji; Paul Cheon; John Peel; Ashley Kirk; Henry Szechtman
Journal:  Psychopharmacology (Berl)       Date:  2014-02-28       Impact factor: 4.530

Review 2.  Obsessive-compulsive disorder: Insights from animal models.

Authors:  Henry Szechtman; Susanne E Ahmari; Richard J Beninger; David Eilam; Brian H Harvey; Henriette Edemann-Callesen; Christine Winter
Journal:  Neurosci Biobehav Rev       Date:  2016-05-07       Impact factor: 8.989

Review 3.  A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward.

Authors:  Geoffrey de Brouwer; Arina Fick; Brian H Harvey; De Wet Wolmarans
Journal:  Cogn Affect Behav Neurosci       Date:  2019-02       Impact factor: 3.282

4.  The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder.

Authors:  Noa Albelda; Nitza Bar-On; Daphna Joel
Journal:  Psychopharmacology (Berl)       Date:  2010-03-19       Impact factor: 4.530

Review 5.  Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment.

Authors:  Christopher Pittenger; Michael H Bloch; Kyle Williams
Journal:  Pharmacol Ther       Date:  2011-09-22       Impact factor: 12.310

6.  Neurocognitive Endophenotypes of OCD.

Authors:  Matilde M Vaghi
Journal:  Curr Top Behav Neurosci       Date:  2021

7.  The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system.

Authors:  Eduardo A Schilman; Oded Klavir; Christine Winter; Reinhard Sohr; Daphna Joel
Journal:  Neuropsychopharmacology       Date:  2010-01-13       Impact factor: 7.853

8.  The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder.

Authors:  Roni Yankelevitch-Yahav; Yankelevitch-Yahav Roni; Dapha Joel; Joel Daphna
Journal:  Psychopharmacology (Berl)       Date:  2013-05-18       Impact factor: 4.530

9.  Developmental estrogen exposures and disruptions to maternal behavior and brain: Effects of ethinyl estradiol, a common positive control.

Authors:  Mary C Catanese; Laura N Vandenberg
Journal:  Horm Behav       Date:  2017-11-08       Impact factor: 3.587

10.  The Differential Effects of the Amount of Training on Sensitivity of Distinct Actions to Reward Devaluation.

Authors:  Maya Bar Or; Oded Klavir
Journal:  Brain Sci       Date:  2021-05-31
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