Literature DB >> 16718275

Diagnostics and biomarker development: priming the pipeline.

Kathryn A Phillips1, Stephanie Van Bebber, Amalia M Issa.   

Abstract

The decrease in the rate at which novel medical products are reaching the market, despite major scientific achievements and investment that might have predicted otherwise, is causing much concern. Although this 'pipeline problem' has often been discussed in the context of drug development, it is also crucial to examine the unique characteristics of the pipeline for biomarkers and diagnostics. Here, we characterize the pipeline problem for biomarkers and diagnostics, and consider what steps could be taken to solve it.

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Year:  2006        PMID: 16718275     DOI: 10.1038/nrd2033

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  28 in total

1.  The interface between biomarker discovery and clinical validation: The tar pit of the protein biomarker pipeline.

Authors:  Amanda G Paulovich; Jeffrey R Whiteaker; Andrew N Hoofnagle; Pei Wang
Journal:  Proteomics Clin Appl       Date:  2008-10-01       Impact factor: 3.494

Review 2.  Quantifying factors for the success of stratified medicine.

Authors:  Mark R Trusheim; Breon Burgess; Sean Xinghua Hu; Theresa Long; Steven D Averbuch; Aiden A Flynn; Alfons Lieftucht; Abhijit Mazumder; Judy Milloy; Peter M Shaw; David Swank; Jian Wang; Ernst R Berndt; Federico Goodsaid; Michael C Palmer
Journal:  Nat Rev Drug Discov       Date:  2011-10-31       Impact factor: 84.694

Review 3.  Transgenic pigs as models for translational biomedical research.

Authors:  Bernhard Aigner; Simone Renner; Barbara Kessler; Nikolai Klymiuk; Mayuko Kurome; Annegret Wünsch; Eckhard Wolf
Journal:  J Mol Med (Berl)       Date:  2010-03-26       Impact factor: 4.599

4.  Pharmacogenomics, evidence, and the role of payers.

Authors:  P A Deverka
Journal:  Public Health Genomics       Date:  2009-02-10       Impact factor: 2.000

5.  Bringing diagnostic technologies to the clinical laboratory: Rigor, regulation, and reality.

Authors:  Gordon Whiteley
Journal:  Proteomics Clin Appl       Date:  2008       Impact factor: 3.494

6.  A Roadmap for the Development of Applied Computational Psychiatry.

Authors:  Martin P Paulus; Quentin J M Huys; Tiago V Maia
Journal:  Biol Psychiatry Cogn Neurosci Neuroimaging       Date:  2016-09

Review 7.  Promise and progress for functional and molecular imaging of response to targeted therapies.

Authors:  Renu M Stephen; Robert J Gillies
Journal:  Pharm Res       Date:  2007-03-24       Impact factor: 4.200

8.  Animal models of virus-induced neurobehavioral sequelae: recent advances, methodological issues, and future prospects.

Authors:  Marco Bortolato; Sean C Godar
Journal:  Interdiscip Perspect Infect Dis       Date:  2010-05-18

Review 9.  Targeted proteomics for biomarker discovery and validation of hepatocellular carcinoma in hepatitis C infected patients.

Authors:  Gul M Mustafa; Denner Larry; John R Petersen; Cornelis J Elferink
Journal:  World J Hepatol       Date:  2015-06-08

10.  Gastric Cancer (Biomarkers) Knowledgebase (GCBKB): A Curated and Fully Integrated Knowledgebase of Putative Biomarkers Related to Gastric Cancer.

Authors:  Bernett T K Lee; Chun Meng Song; Boon Huat Yeo; Cheuk Wang Chung; Ying Leong Chan; Teng Ting Lim; Yen Bing Chua; Marie C S Loh; Boon Keong Ang; Praveen Vijayakumar; Lailing Liew; Jiahao Lim; Yun Ping Lim; Chee Hong Wong; Danny Chuon; Gunaretnam Rajagopal; Jeffrey Hill
Journal:  Biomark Insights       Date:  2007-02-07
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