Literature DB >> 16717429

Degradation of PrP(Sc) by keratinolytic protease from Nocardiopsis sp. TOA-1.

Shinji Mitsuiki1, Zhao Hui, Daishi Matsumoto, Masashi Sakai, Yasushi Moriyama, Kensuke Furukawa, Hiroaki Kanouchi, Tatsuzo Oka.   

Abstract

A keratinolytic alkaline proteae (NAPase) from Nocardiopsis sp. TOA-1 degraded a scrapie prion without any chemical or physical treatment. Optimal temperature and pH were 60 degrees C and above pH 10.0. The scrapie prion was completely degraded within 3 min under optimal conditions.

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Year:  2006        PMID： 16717429     DOI： 10.1271/bbb.70.1246

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

1.  High CJD infectivity remains after prion protein is destroyed.

Authors:  Kohtaro Miyazawa; Kaitlin Emmerling; Laura Manuelidis
Journal:  J Cell Biochem       Date:  2011-12       Impact factor: 4.429

Review 2.  Fate of prions in soil: a review.

Authors:  Christen B Smith; Clarissa J Booth; Joel A Pedersen
Journal:  J Environ Qual       Date:  2011 Mar-Apr       Impact factor: 2.751

3.  Characterization of a novel Stenotrophomonas isolate with high keratinase activity and purification of the enzyme.

Authors:  Zhang-Jun Cao; Qi Zhang; Dong-Kai Wei; Li Chen; Jing Wang; Xing-Qun Zhang; Mei-Hua Zhou
Journal:  J Ind Microbiol Biotechnol       Date:  2009-01-10       Impact factor: 3.346

4.  Enzymatic degradation of PrPSc by a protease secreted from Aeropyrum pernix K1.

Authors:  Marko Snajder; Tanja Vilfan; Maja Cernilec; Ruth Rupreht; Mara Popović; Polona Juntes; Vladka Čurin Serbec; Nataša Poklar Ulrih
Journal:  PLoS One       Date:  2012-06-28       Impact factor: 3.240

5.  Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting.

Authors:  Qi Yuan; Thomas Eckland; Glenn Telling; Jason Bartz; Shannon Bartelt-Hunt
Journal:  PLoS Pathog       Date:  2015-02-09       Impact factor: 6.823

6.  Microbial keratinase and the bio-economy: a three-decade meta-analysis of research exploit.

Authors:  Nonso E Nnolim; Uchechukwu U Nwodo
Journal:  AMB Express       Date:  2021-01-07       Impact factor: 3.298

Review 7.  Microbial enzymes catalyzing keratin degradation: Classification, structure, function.

Authors:  Jingwen Qiu; Casper Wilkens; Kristian Barrett; Anne S Meyer
Journal:  Biotechnol Adv       Date:  2020-08-05       Impact factor: 14.227
  7 in total

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